Necrotizing Cavitary Pneumonia by Serratia marcescens in a Patient Treated With Dupilumab: Correlation or Causation?
Serratia species are gram-negative bacilli causing opportunistic and nosocomial infections, often in patients who are immunocompromised. A 61-year-old man with severe asthma receiving dupilumab presented with fever and chills. A chest computed tomography scan revealed bilateral cavitary lesions sugg...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2025-06-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2025.0205 |
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| Summary: | Serratia species are gram-negative bacilli causing opportunistic and nosocomial infections, often in patients who are immunocompromised. A 61-year-old man with severe asthma receiving dupilumab presented with fever and chills. A chest computed tomography scan revealed bilateral cavitary lesions suggestive of necrotizing pneumonia. Bronchoalveolar lavage grew Serratia marcescens, and he was treated with prolonged antibiotics. Serratia marcescens should be considered in necrotizing pneumonia, even in patients who are immunocompetent, with dupilumab potentially as the inciting factor. |
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| ISSN: | 2767-7664 |