Signal transmission through excitable media by an oscillatory source
Living organisms transmit signals through local interactions with their neighbors. However, the precise timing of signals is fundamentally challenged by the presence of numerous stochastic reactions within interacting cells. Here we develop a minimal model to investigate the strength of signal propa...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2025-03-01
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| Series: | Physical Review Research |
| Online Access: | http://doi.org/10.1103/PhysRevResearch.7.L012051 |
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| _version_ | 1850042883982229504 |
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| author | Lukas W. Kristensen Michael Lisby Mogens H. Jensen Mathias S. Heltberg |
| author_facet | Lukas W. Kristensen Michael Lisby Mogens H. Jensen Mathias S. Heltberg |
| author_sort | Lukas W. Kristensen |
| collection | DOAJ |
| description | Living organisms transmit signals through local interactions with their neighbors. However, the precise timing of signals is fundamentally challenged by the presence of numerous stochastic reactions within interacting cells. Here we develop a minimal model to investigate the strength of signal propagation in stochastic environments. We uncover a multimodal frequency dependency with a few local optima, which is robust in both one and two dimensions. Through mathematical analysis we explain the frequency dependency and uncover the interplay between stochasticity and external frequency in order to optimize the signaling strength of the system. Finally we investigate the possibilities of bidirectional reactions in the oscillating source, allowing us to define thermodynamic properties of the system and investigate the relationship between free-energy dissipation and precision of signaling, showing nontrivial frequency dependency in coupled cells. |
| format | Article |
| id | doaj-art-eb201895e4974bacb8de4b6fc15a44f1 |
| institution | DOAJ |
| issn | 2643-1564 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review Research |
| spelling | doaj-art-eb201895e4974bacb8de4b6fc15a44f12025-08-20T02:55:24ZengAmerican Physical SocietyPhysical Review Research2643-15642025-03-0171L01205110.1103/PhysRevResearch.7.L012051Signal transmission through excitable media by an oscillatory sourceLukas W. KristensenMichael LisbyMogens H. JensenMathias S. HeltbergLiving organisms transmit signals through local interactions with their neighbors. However, the precise timing of signals is fundamentally challenged by the presence of numerous stochastic reactions within interacting cells. Here we develop a minimal model to investigate the strength of signal propagation in stochastic environments. We uncover a multimodal frequency dependency with a few local optima, which is robust in both one and two dimensions. Through mathematical analysis we explain the frequency dependency and uncover the interplay between stochasticity and external frequency in order to optimize the signaling strength of the system. Finally we investigate the possibilities of bidirectional reactions in the oscillating source, allowing us to define thermodynamic properties of the system and investigate the relationship between free-energy dissipation and precision of signaling, showing nontrivial frequency dependency in coupled cells.http://doi.org/10.1103/PhysRevResearch.7.L012051 |
| spellingShingle | Lukas W. Kristensen Michael Lisby Mogens H. Jensen Mathias S. Heltberg Signal transmission through excitable media by an oscillatory source Physical Review Research |
| title | Signal transmission through excitable media by an oscillatory source |
| title_full | Signal transmission through excitable media by an oscillatory source |
| title_fullStr | Signal transmission through excitable media by an oscillatory source |
| title_full_unstemmed | Signal transmission through excitable media by an oscillatory source |
| title_short | Signal transmission through excitable media by an oscillatory source |
| title_sort | signal transmission through excitable media by an oscillatory source |
| url | http://doi.org/10.1103/PhysRevResearch.7.L012051 |
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