Clinical application of metagenomic next-generation sequencing in purulent meningitis: a case seri
Background. Purulent meningitis remains an important cause of mortality and morbidity among children worldwide. An immediate diagnosis of the causative microorganism is critical to significantly improving the outcome of this condition. Case. In this study, we collected cerebrospinal fl...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2023-08-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/76 |
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| author | Min Ding Chunfeng Yang Yumei Li |
| author_facet | Min Ding Chunfeng Yang Yumei Li |
| author_sort | Min Ding |
| collection | DOAJ |
| description |
Background. Purulent meningitis remains an important cause of mortality and morbidity among children worldwide. An immediate diagnosis of the causative microorganism is critical to significantly improving the outcome of this condition.
Case. In this study, we collected cerebrospinal fluid (CSF) samples from four patients clinically diagnosed with purulent meningitis. Patients with purulent meningitis may present with a variety of clinical symptoms or laboratory results. Infectious microorganisms including Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumonia, and Haemophilus influenzae were identified in the CSF samples via metagenomic nextgeneration sequencing (mNGS).
Conclusions. mNGS is effective for the immediate detection of pathogens, which can in turn facilitate prompt diagnosis and treatment among individuals with purulent meningitis, especially if conventional CSF results (such as CSF culture and polymerase chain reaction) are negative.
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| format | Article |
| id | doaj-art-eb1f38153e2c4ffcb89b730051f09a2f |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-eb1f38153e2c4ffcb89b730051f09a2f2025-08-20T02:55:38ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212023-08-0165410.24953/turkjped.2022.691Clinical application of metagenomic next-generation sequencing in purulent meningitis: a case seriMin Ding0Chunfeng Yang1Yumei Li2Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. Background. Purulent meningitis remains an important cause of mortality and morbidity among children worldwide. An immediate diagnosis of the causative microorganism is critical to significantly improving the outcome of this condition. Case. In this study, we collected cerebrospinal fluid (CSF) samples from four patients clinically diagnosed with purulent meningitis. Patients with purulent meningitis may present with a variety of clinical symptoms or laboratory results. Infectious microorganisms including Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumonia, and Haemophilus influenzae were identified in the CSF samples via metagenomic nextgeneration sequencing (mNGS). Conclusions. mNGS is effective for the immediate detection of pathogens, which can in turn facilitate prompt diagnosis and treatment among individuals with purulent meningitis, especially if conventional CSF results (such as CSF culture and polymerase chain reaction) are negative. https://turkjpediatr.org/article/view/76case seriesdiagnosismetagenomic next-generation sequencingpediatricspurulent meningitis |
| spellingShingle | Min Ding Chunfeng Yang Yumei Li Clinical application of metagenomic next-generation sequencing in purulent meningitis: a case seri The Turkish Journal of Pediatrics case series diagnosis metagenomic next-generation sequencing pediatrics purulent meningitis |
| title | Clinical application of metagenomic next-generation sequencing in purulent meningitis: a case seri |
| title_full | Clinical application of metagenomic next-generation sequencing in purulent meningitis: a case seri |
| title_fullStr | Clinical application of metagenomic next-generation sequencing in purulent meningitis: a case seri |
| title_full_unstemmed | Clinical application of metagenomic next-generation sequencing in purulent meningitis: a case seri |
| title_short | Clinical application of metagenomic next-generation sequencing in purulent meningitis: a case seri |
| title_sort | clinical application of metagenomic next generation sequencing in purulent meningitis a case seri |
| topic | case series diagnosis metagenomic next-generation sequencing pediatrics purulent meningitis |
| url | https://turkjpediatr.org/article/view/76 |
| work_keys_str_mv | AT minding clinicalapplicationofmetagenomicnextgenerationsequencinginpurulentmeningitisacaseseri AT chunfengyang clinicalapplicationofmetagenomicnextgenerationsequencinginpurulentmeningitisacaseseri AT yumeili clinicalapplicationofmetagenomicnextgenerationsequencinginpurulentmeningitisacaseseri |