The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials
Abstract Non-nutritive sweeteners (NNS) have been suggested as a viable solution to reduce sugar consumption. However, conflicting and uncertain evidence regarding their impact on lipid profile exists. This meta-analysis assesses the effects of different types of NNS on lipid profile markers. PubMed...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-00612-3 |
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| author | AmirHossein Najafi Fatemeh Moghtaderi Behnaz Seyedjafari Kimia Rostampour Amin Salehi-Abargouei |
| author_facet | AmirHossein Najafi Fatemeh Moghtaderi Behnaz Seyedjafari Kimia Rostampour Amin Salehi-Abargouei |
| author_sort | AmirHossein Najafi |
| collection | DOAJ |
| description | Abstract Non-nutritive sweeteners (NNS) have been suggested as a viable solution to reduce sugar consumption. However, conflicting and uncertain evidence regarding their impact on lipid profile exists. This meta-analysis assesses the effects of different types of NNS on lipid profile markers. PubMed, Web of Science ISI, Scopus, and Google Scholar were searched for relevant articles up to September 2024. The Cochrane Collaboration tool was used for the quality assessment, and the evidence’s trustworthiness was assessed using the Grading of Assessment, Development, and Evaluation of Recommendations (GRADE). A total of 28 articles revealed that NNS might not have a significant effect on serum triglycerides (Weighted mean difference (WMD): -2.66, 95% confidence interval (CI): -6.29, 0.98 mg/dL, n = 2209, level of confidence: low), total cholesterol (WMD: -0.44, 95% CI: -2.96, 2.08 mg/dl, n = 2047, level of confidence: low), high-density lipoprotein cholesterol (WMD: 0.03, 95% CI: -0.68, 0.74 mg/dl, n = 2097, level of confidence: low), low-density lipoprotein cholesterol (WMD: 0.51, 95% CI: -1.57, 2.59 mg/dl, n = 1777, level of confidence: low) and very low-density lipoprotein (WMD: 2.20, 95% CI: -2.66, 7.06 mg/dl, n = 154, level of confidence: very low). It is demonstrated that NNS might not affect serum lipid profile. |
| format | Article |
| id | doaj-art-eb1bb237beca48e6919d04122e927d42 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-eb1bb237beca48e6919d04122e927d422025-08-20T03:38:12ZengNature PortfolioScientific Reports2045-23222025-07-0115112010.1038/s41598-025-00612-3The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trialsAmirHossein Najafi0Fatemeh Moghtaderi1Behnaz Seyedjafari2Kimia Rostampour3Amin Salehi-Abargouei4Student Research Committee, Shahid Sadoughi University of Medical SciencesStudent Research Committee, Shahid Sadoughi University of Medical SciencesStudent Research Committee, Shahid Sadoughi University of Medical SciencesStudent Research Committee, Shahid Sadoughi University of Medical SciencesResearch Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical SciencesAbstract Non-nutritive sweeteners (NNS) have been suggested as a viable solution to reduce sugar consumption. However, conflicting and uncertain evidence regarding their impact on lipid profile exists. This meta-analysis assesses the effects of different types of NNS on lipid profile markers. PubMed, Web of Science ISI, Scopus, and Google Scholar were searched for relevant articles up to September 2024. The Cochrane Collaboration tool was used for the quality assessment, and the evidence’s trustworthiness was assessed using the Grading of Assessment, Development, and Evaluation of Recommendations (GRADE). A total of 28 articles revealed that NNS might not have a significant effect on serum triglycerides (Weighted mean difference (WMD): -2.66, 95% confidence interval (CI): -6.29, 0.98 mg/dL, n = 2209, level of confidence: low), total cholesterol (WMD: -0.44, 95% CI: -2.96, 2.08 mg/dl, n = 2047, level of confidence: low), high-density lipoprotein cholesterol (WMD: 0.03, 95% CI: -0.68, 0.74 mg/dl, n = 2097, level of confidence: low), low-density lipoprotein cholesterol (WMD: 0.51, 95% CI: -1.57, 2.59 mg/dl, n = 1777, level of confidence: low) and very low-density lipoprotein (WMD: 2.20, 95% CI: -2.66, 7.06 mg/dl, n = 154, level of confidence: very low). It is demonstrated that NNS might not affect serum lipid profile.https://doi.org/10.1038/s41598-025-00612-3Artificial sweetenersTotal cholesterolTriglycerideLow-density lipoproteinHigh-density lipoproteinVery low-density lipoprotein |
| spellingShingle | AmirHossein Najafi Fatemeh Moghtaderi Behnaz Seyedjafari Kimia Rostampour Amin Salehi-Abargouei The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials Scientific Reports Artificial sweeteners Total cholesterol Triglyceride Low-density lipoprotein High-density lipoprotein Very low-density lipoprotein |
| title | The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials |
| title_full | The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials |
| title_fullStr | The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials |
| title_full_unstemmed | The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials |
| title_short | The effects of non-nutritive sweeteners on lipid profile in adults: a systematic review and meta-analysis of randomized controlled clinical trials |
| title_sort | effects of non nutritive sweeteners on lipid profile in adults a systematic review and meta analysis of randomized controlled clinical trials |
| topic | Artificial sweeteners Total cholesterol Triglyceride Low-density lipoprotein High-density lipoprotein Very low-density lipoprotein |
| url | https://doi.org/10.1038/s41598-025-00612-3 |
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