The P132H mutation of SARS-CoV-2 NSP5 relieves its inhibition on interferon-β activation via blocking MAVS degradation

The P132H mutation of SARS-CoV-2 NSP5 relieves its inhibition on interferon-β activation via blocking MAVS degradation

Abstract The prevalence of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important transition in the epidemic of coronavirus disease 2019 (COVID-19). Compared with other SARS-CoV-2 variants, Omicron and its subvariants exhibit decreased pathogenicity, thus...

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Bibliographic Details
Main Authors: Yuxin Zhang, Tong-Yun Wang, Huihui Yan, Zhoule Guo, Zhonghao Lian, Hailan Yao, Shuofeng Yuan, Xing-Yi Ge, Ye Qiu
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cellular and Molecular Life Sciences
Subjects:
SARS-CoV-2 variants
P132H
IFN-β
MAVS
NSP5
Online Access:https://doi.org/10.1007/s00018-025-05822-6
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