Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and early-onset benign prostatic hyperplasia: a cross-sectional analysis based on NHANES
Abstract Background The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), a biomarker of lipid metabolism, has been used to predict cardiovascular disease incidence. However, its association with early-onset benign prostatic hyperplasia (BPH) remains uncl...
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2025-08-01
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| Series: | Journal of Health, Population and Nutrition |
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| Online Access: | https://doi.org/10.1186/s41043-025-01048-1 |
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| author | Pengfei Ta Wei Guo Baishun Li Chunlei Xiao Ke Liu Shudong Zhang Ruotao Xiao |
| author_facet | Pengfei Ta Wei Guo Baishun Li Chunlei Xiao Ke Liu Shudong Zhang Ruotao Xiao |
| author_sort | Pengfei Ta |
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| description | Abstract Background The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), a biomarker of lipid metabolism, has been used to predict cardiovascular disease incidence. However, its association with early-onset benign prostatic hyperplasia (BPH) remains unclear. This study aimed to investigate the relationship between NHHR and the risk of early-onset BPH. Methods Data were obtained from the National Health and Nutrition Examination Survey (NHANES) in the United States between 2005 and 2008. NHHR was calculated as the ratio of non-HDL-C to HDL-C. Weighted multivariable logistic regression models were used to assess the association after adjusting for potential confounders. Results A total of 530 participants were included, with a median onset age of 60 years. Participants were divided into early-onset and late-onset BPH groups based on the median age. The early-onset group had higher rates of current smoking, education level, poverty-income ratio (PIR), BMI, NHHR, and total cholesterol compared to the late-onset group. After full adjustment, elevated NHHR was significantly associated with increased odds of early-onset BPH (OR = 1.35; 95% CI 1.09–1.68; P = 0.010). Additionally, higher NHHR was associated with a younger age of BPH onset (exp(β) = 0.17; 95% CI 0.07–0.42; P < 0.001). Subgroup analysis showed that this association was observed in most subgroups. Conclusion Elevated NHHR is positively associated with early-onset BPH. Further prospective studies are needed to explore the role of lipid metabolism in prostate disease. |
| format | Article |
| id | doaj-art-eb131469f2f64e2f8cd2f3cd5655fd5f |
| institution | Kabale University |
| issn | 2072-1315 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
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| series | Journal of Health, Population and Nutrition |
| spelling | doaj-art-eb131469f2f64e2f8cd2f3cd5655fd5f2025-08-24T11:35:32ZengBMCJournal of Health, Population and Nutrition2072-13152025-08-014411910.1186/s41043-025-01048-1Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and early-onset benign prostatic hyperplasia: a cross-sectional analysis based on NHANESPengfei Ta0Wei Guo1Baishun Li2Chunlei Xiao3Ke Liu4Shudong Zhang5Ruotao Xiao6Department of Urology, Peking University Third HospitalDepartment of Urology, Yan’an Traditional Chinese Medicine HospitalDepartment of Urology, Xishuangbanna Dai Autonomous Prefecture People’s HospitalDepartment of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalDepartment of Urology, Peking University Third HospitalAbstract Background The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), a biomarker of lipid metabolism, has been used to predict cardiovascular disease incidence. However, its association with early-onset benign prostatic hyperplasia (BPH) remains unclear. This study aimed to investigate the relationship between NHHR and the risk of early-onset BPH. Methods Data were obtained from the National Health and Nutrition Examination Survey (NHANES) in the United States between 2005 and 2008. NHHR was calculated as the ratio of non-HDL-C to HDL-C. Weighted multivariable logistic regression models were used to assess the association after adjusting for potential confounders. Results A total of 530 participants were included, with a median onset age of 60 years. Participants were divided into early-onset and late-onset BPH groups based on the median age. The early-onset group had higher rates of current smoking, education level, poverty-income ratio (PIR), BMI, NHHR, and total cholesterol compared to the late-onset group. After full adjustment, elevated NHHR was significantly associated with increased odds of early-onset BPH (OR = 1.35; 95% CI 1.09–1.68; P = 0.010). Additionally, higher NHHR was associated with a younger age of BPH onset (exp(β) = 0.17; 95% CI 0.07–0.42; P < 0.001). Subgroup analysis showed that this association was observed in most subgroups. Conclusion Elevated NHHR is positively associated with early-onset BPH. Further prospective studies are needed to explore the role of lipid metabolism in prostate disease.https://doi.org/10.1186/s41043-025-01048-1Lipid metabolismProstatic hyperplasiaNutrition surveysCross-sectional studies |
| spellingShingle | Pengfei Ta Wei Guo Baishun Li Chunlei Xiao Ke Liu Shudong Zhang Ruotao Xiao Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and early-onset benign prostatic hyperplasia: a cross-sectional analysis based on NHANES Journal of Health, Population and Nutrition Lipid metabolism Prostatic hyperplasia Nutrition surveys Cross-sectional studies |
| title | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and early-onset benign prostatic hyperplasia: a cross-sectional analysis based on NHANES |
| title_full | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and early-onset benign prostatic hyperplasia: a cross-sectional analysis based on NHANES |
| title_fullStr | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and early-onset benign prostatic hyperplasia: a cross-sectional analysis based on NHANES |
| title_full_unstemmed | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and early-onset benign prostatic hyperplasia: a cross-sectional analysis based on NHANES |
| title_short | Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and early-onset benign prostatic hyperplasia: a cross-sectional analysis based on NHANES |
| title_sort | association between the non high density lipoprotein cholesterol to high density lipoprotein cholesterol ratio nhhr and early onset benign prostatic hyperplasia a cross sectional analysis based on nhanes |
| topic | Lipid metabolism Prostatic hyperplasia Nutrition surveys Cross-sectional studies |
| url | https://doi.org/10.1186/s41043-025-01048-1 |
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