Development and validation of a predictive model for acute kidney injury in patients with ureterolithiasis
Objectives This study aims to identify risk factors for acute kidney injury (AKI) in patients with ureterolithiasis and to develop a predictive model for early AKI detection in this population.Methods A retrospective analysis was conducted on data from 1,016 patients with ureterolithiasis who presen...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2394634 |
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| author | Yufeng Jiang Jingcheng Zhang Ailiyaer Ainiwaer Yuchao Liu Jing Li Liuliu Zhou Yang Yan Haimin Zhang |
| author_facet | Yufeng Jiang Jingcheng Zhang Ailiyaer Ainiwaer Yuchao Liu Jing Li Liuliu Zhou Yang Yan Haimin Zhang |
| author_sort | Yufeng Jiang |
| collection | DOAJ |
| description | Objectives This study aims to identify risk factors for acute kidney injury (AKI) in patients with ureterolithiasis and to develop a predictive model for early AKI detection in this population.Methods A retrospective analysis was conducted on data from 1,016 patients with ureterolithiasis who presented to our outpatient emergency department between January 2021 and December 2022. Using multifactorial logistic regression, we identified independent risk factors for AKI and constructed a nomogram to predict AKI risk. The predictive model’s efficacy was assessed through the area under the ROC curve, calibration curves, Hosmer-Lemeshow (HL) test, and decision curve analysis (DCA).Results AKI was diagnosed in 18.7% of the patients. Independent risk factors identified included age, fever, diabetes, hyperuricemia, bilateral calculi, functional solitary kidney, self-medication, and prehospital delay. The nomogram demonstrated excellent discriminatory capabilities, with AUCs of 0.818 (95% CI, 0.775–0.861) for the modeling set and 0.782 (95% CI, 0.708–0.856) for the validation set. Both calibration curve and HL test results confirmed strong concordance between the model’s predictions and actual observations. DCA highlighted the model’s significant clinical utility.Conclusions The predictive model developed in this study provides clinicians with a valuable tool for early identification and management of patients at high risk for AKI, thereby potentially enhancing patient outcomes. |
| format | Article |
| id | doaj-art-eb10debd2d4b46a2b20d3d1529411ea6 |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-eb10debd2d4b46a2b20d3d1529411ea62025-08-20T02:29:58ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2394634Development and validation of a predictive model for acute kidney injury in patients with ureterolithiasisYufeng Jiang0Jingcheng Zhang1Ailiyaer Ainiwaer2Yuchao Liu3Jing Li4Liuliu Zhou5Yang Yan6Haimin Zhang7School of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Tongji University, Shanghai, ChinaDepartment of Urology, Chongming Branch, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaMedical Department, Chongming Branch, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Urology, Chongming Branch, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Urology, Chongming Branch, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaObjectives This study aims to identify risk factors for acute kidney injury (AKI) in patients with ureterolithiasis and to develop a predictive model for early AKI detection in this population.Methods A retrospective analysis was conducted on data from 1,016 patients with ureterolithiasis who presented to our outpatient emergency department between January 2021 and December 2022. Using multifactorial logistic regression, we identified independent risk factors for AKI and constructed a nomogram to predict AKI risk. The predictive model’s efficacy was assessed through the area under the ROC curve, calibration curves, Hosmer-Lemeshow (HL) test, and decision curve analysis (DCA).Results AKI was diagnosed in 18.7% of the patients. Independent risk factors identified included age, fever, diabetes, hyperuricemia, bilateral calculi, functional solitary kidney, self-medication, and prehospital delay. The nomogram demonstrated excellent discriminatory capabilities, with AUCs of 0.818 (95% CI, 0.775–0.861) for the modeling set and 0.782 (95% CI, 0.708–0.856) for the validation set. Both calibration curve and HL test results confirmed strong concordance between the model’s predictions and actual observations. DCA highlighted the model’s significant clinical utility.Conclusions The predictive model developed in this study provides clinicians with a valuable tool for early identification and management of patients at high risk for AKI, thereby potentially enhancing patient outcomes.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2394634Acute kidney injurypredictive modelinglogistic regressionureterolithiasis |
| spellingShingle | Yufeng Jiang Jingcheng Zhang Ailiyaer Ainiwaer Yuchao Liu Jing Li Liuliu Zhou Yang Yan Haimin Zhang Development and validation of a predictive model for acute kidney injury in patients with ureterolithiasis Renal Failure Acute kidney injury predictive modeling logistic regression ureterolithiasis |
| title | Development and validation of a predictive model for acute kidney injury in patients with ureterolithiasis |
| title_full | Development and validation of a predictive model for acute kidney injury in patients with ureterolithiasis |
| title_fullStr | Development and validation of a predictive model for acute kidney injury in patients with ureterolithiasis |
| title_full_unstemmed | Development and validation of a predictive model for acute kidney injury in patients with ureterolithiasis |
| title_short | Development and validation of a predictive model for acute kidney injury in patients with ureterolithiasis |
| title_sort | development and validation of a predictive model for acute kidney injury in patients with ureterolithiasis |
| topic | Acute kidney injury predictive modeling logistic regression ureterolithiasis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2394634 |
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