Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades
ABSTRACT Background Stereotactic radiosurgery, a minimally invasive treatment delivering high doses of radiation to a well‐defined target, has transformed interdisciplinary treatment paradigms since its inception. This study chronicles its adoption and evolution for brain cancer and tumors globally....
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| Format: | Article |
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Wiley
2025-03-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70673 |
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| author | Zerubbabel K. Asfaw Tirone Young Cole Brown Mehek Dedhia Lily Huo Kunal K. Sindhu Stanislav Lazarev Robert Samstein Sheryl Green Isabelle M. Germano |
| author_facet | Zerubbabel K. Asfaw Tirone Young Cole Brown Mehek Dedhia Lily Huo Kunal K. Sindhu Stanislav Lazarev Robert Samstein Sheryl Green Isabelle M. Germano |
| author_sort | Zerubbabel K. Asfaw |
| collection | DOAJ |
| description | ABSTRACT Background Stereotactic radiosurgery, a minimally invasive treatment delivering high doses of radiation to a well‐defined target, has transformed interdisciplinary treatment paradigms since its inception. This study chronicles its adoption and evolution for brain cancer and tumors globally. Methods A systematic literature review of SRS‐focused articles from 2000 to 2023 was conducted. Literature impact was evaluated using citation counts and relative citation ratio scores. Extracted data were dichotomized between US and international publications. Results Out of 5424 articles eligible, 538 met inclusion criteria reporting on 120,756 patients treated with SRS for brain cancer and tumors since 2000. Over time, publication rates grew significantly (p = 0.0016), with 56% of principal investigators based in the United States. Clinical articles accounted for 87% of the publications, with the remainder focused on technological advances. Relative to international studies, US publications had larger median samples (74 vs. 58, p = 0.012), higher median citations (30 vs. 19, p < 0.0001) and higher relative citation ratio scores (1.67 vs. 1.2, p < 0.00001). Gamma Knife and LINAC had roughly equal representation in US and international publications. Neurosurgery specialists authored more Gamma Knife‐based articles, and radiation oncology specialists authored more LINAC‐based papers (p < 0.0001). The most treated tumors were metastases (58%), skull base tumors (35%), and gliomas (7%). Radiographic control was achieved in 82% of metastatic tumor cases, with a 12% median complication rate. Conclusions SRS has been widely adopted both nationally and globally and continues to be a growing field. This study corroborates the clinical efficacy of SRS and reinforces its critical role in the multidisciplinary treatment of patients with brain tumors and cancer. |
| format | Article |
| id | doaj-art-eb0e80e5a69846bc9223c01f9a7fd5e6 |
| institution | OA Journals |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-eb0e80e5a69846bc9223c01f9a7fd5e62025-08-20T02:16:10ZengWileyCancer Medicine2045-76342025-03-01146n/an/a10.1002/cam4.70673Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two DecadesZerubbabel K. Asfaw0Tirone Young1Cole Brown2Mehek Dedhia3Lily Huo4Kunal K. Sindhu5Stanislav Lazarev6Robert Samstein7Sheryl Green8Isabelle M. Germano9Department of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USADepartment of Radiation Oncology Icahn School of Medicine at Mount Sinai New York New York USADepartment of Radiation Oncology Icahn School of Medicine at Mount Sinai New York New York USADepartment of Radiation Oncology Icahn School of Medicine at Mount Sinai New York New York USADepartment of Radiation Oncology Icahn School of Medicine at Mount Sinai New York New York USADepartment of Neurosurgery Icahn School of Medicine at Mount Sinai New York New York USAABSTRACT Background Stereotactic radiosurgery, a minimally invasive treatment delivering high doses of radiation to a well‐defined target, has transformed interdisciplinary treatment paradigms since its inception. This study chronicles its adoption and evolution for brain cancer and tumors globally. Methods A systematic literature review of SRS‐focused articles from 2000 to 2023 was conducted. Literature impact was evaluated using citation counts and relative citation ratio scores. Extracted data were dichotomized between US and international publications. Results Out of 5424 articles eligible, 538 met inclusion criteria reporting on 120,756 patients treated with SRS for brain cancer and tumors since 2000. Over time, publication rates grew significantly (p = 0.0016), with 56% of principal investigators based in the United States. Clinical articles accounted for 87% of the publications, with the remainder focused on technological advances. Relative to international studies, US publications had larger median samples (74 vs. 58, p = 0.012), higher median citations (30 vs. 19, p < 0.0001) and higher relative citation ratio scores (1.67 vs. 1.2, p < 0.00001). Gamma Knife and LINAC had roughly equal representation in US and international publications. Neurosurgery specialists authored more Gamma Knife‐based articles, and radiation oncology specialists authored more LINAC‐based papers (p < 0.0001). The most treated tumors were metastases (58%), skull base tumors (35%), and gliomas (7%). Radiographic control was achieved in 82% of metastatic tumor cases, with a 12% median complication rate. Conclusions SRS has been widely adopted both nationally and globally and continues to be a growing field. This study corroborates the clinical efficacy of SRS and reinforces its critical role in the multidisciplinary treatment of patients with brain tumors and cancer.https://doi.org/10.1002/cam4.70673Gamma Knifeglobal neurosurgerylinear acceleratorneuro‐oncologyneurosurgeryradiation oncology |
| spellingShingle | Zerubbabel K. Asfaw Tirone Young Cole Brown Mehek Dedhia Lily Huo Kunal K. Sindhu Stanislav Lazarev Robert Samstein Sheryl Green Isabelle M. Germano Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades Cancer Medicine Gamma Knife global neurosurgery linear accelerator neuro‐oncology neurosurgery radiation oncology |
| title | Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades |
| title_full | Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades |
| title_fullStr | Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades |
| title_full_unstemmed | Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades |
| title_short | Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades |
| title_sort | transforming brain tumor care the global impact of radiosurgery in multidisciplinary treatment over two decades |
| topic | Gamma Knife global neurosurgery linear accelerator neuro‐oncology neurosurgery radiation oncology |
| url | https://doi.org/10.1002/cam4.70673 |
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