Clinical utility of liquid biopsy next-generation sequencing for advanced non-small cell lung cancer in the Netherlands

Clinical utility of liquid biopsy next-generation sequencing for advanced non-small cell lung cancer in the Netherlands

Abstract Tumor molecular profiling is essential for therapeutic management of advanced non-small cell lung cancer (NSCLC). However, a biopsy is not for every patient possible and can have complications, which plasma derived circulating tumor DNA (ctDNA) analysis could overcome. We assessed the clini...

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Main Authors: Tessa J. J. de Bitter, Maartje J. Geerlings, Leonie I. Kroeze, Daniel von Rhein, Milou M. F. Schuurbiers, Janne M. Bibbe, Joyce A. M. G. Smeijers, Hicham Ouchene, Christian Gilissen, Tom G. J. Hofste, Marjan M. Weiss, Longkankernet, Lisenka E. L. M. Vissers, Michel M. van den Heuvel, Marjolijn J. L. Ligtenberg
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Liquid biopsy
Circulating tumor DNA
Clinical utility
Non-small cell lung cancer
Actionable driver
Diagnostic yield
Online Access:https://doi.org/10.1038/s41598-025-13667-z
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