A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers

A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers

Abstract Background The APOE ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and is associated with increased risk of amyloid-related imaging abnormalities (ARIA) during anti-amyloid therapy. Accurate identification of ε4 carriers, particularly APOE ε4/ε4 indiv...

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Bibliographic Details
Main Authors: Andrés Rodríguez, Olga Calero, Sergio Veiga, Miriam Menacho-Román, Ignacio Arribas, Lluís Cano, Guillermo García-Ribas, Miguel Calero
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Apolipoprotein E4 (ApoE4)
Alzheimer's disease (AD)
Biochemical assay
Plasma biomarkers
Non-genetic test
Amyloid-related imaging abnormalities (ARIA)
Online Access:https://doi.org/10.1186/s13195-025-01811-w
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