Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products
Knee osteoarthritis (OA) is a chronic articular disease characterized by the progressive degeneration of cartilage and bone tissue, leading to the appearance of subchondral cysts, osteophyte formation, and synovial inflammation. Conventional treatments consist of non-steroidal anti-inflammatory drug...
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MDPI AG
2024-12-01
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| author | José Fábio Lana Joseph Purita Madhan Jeyaraman Bianca Freitas de Souza Bruno Lima Rodrigues Stephany Cares Huber Carolina Caliari Gabriel Silva Santos Lucas Furtado da Fonseca Ignacio Dallo Annu Navani Marco Antônio Percope De Andrade Peter Albert Everts |
| author_facet | José Fábio Lana Joseph Purita Madhan Jeyaraman Bianca Freitas de Souza Bruno Lima Rodrigues Stephany Cares Huber Carolina Caliari Gabriel Silva Santos Lucas Furtado da Fonseca Ignacio Dallo Annu Navani Marco Antônio Percope De Andrade Peter Albert Everts |
| author_sort | José Fábio Lana |
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| description | Knee osteoarthritis (OA) is a chronic articular disease characterized by the progressive degeneration of cartilage and bone tissue, leading to the appearance of subchondral cysts, osteophyte formation, and synovial inflammation. Conventional treatments consist of non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, and glucocorticoids. However, the prolonged use of these drugs causes adverse effects. NSAIDs, for instance, are known to be nephrotoxic, increasing the damage to articular cartilage. New therapies capable of accelerating the process of tissue regeneration and repair are being discussed, such as the use of orthobiologics that are naturally found in the body and obtained through minimally invasive collection and/or laboratory manipulations. Bone marrow aspirate (BMA) and bone marrow aspirate concentrate (BMAC) are both rich in hematopoietic stem cells, mesenchymal stem cells (MSCs), and growth factors (GFs) that can be used in the healing process due to their anabolic and anti-inflammatory effects. The aim of this literature review is to assess the efficacy of BMA and BMAC in the treatment of knee OA based on the favorable results that researchers have obtained with the use of both orthobiologics envisaging an accelerated healing process and the prevention of OA progression. |
| format | Article |
| id | doaj-art-eb06501facf84423837ae59e740482a4 |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-eb06501facf84423837ae59e740482a42025-08-20T02:00:51ZengMDPI AGBiomedicines2227-90592024-12-011212281210.3390/biomedicines12122812Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived ProductsJosé Fábio Lana0Joseph Purita1Madhan Jeyaraman2Bianca Freitas de Souza3Bruno Lima Rodrigues4Stephany Cares Huber5Carolina Caliari6Gabriel Silva Santos7Lucas Furtado da Fonseca8Ignacio Dallo9Annu Navani10Marco Antônio Percope De Andrade11Peter Albert Everts12Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, BrazilMedical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, BrazilRegenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, BrazilDepartment of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, BrazilRegenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, BrazilRegenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, BrazilCell Therapy, In Situ Terapia Celular, Ribeirão Preto 14056-680, SP, BrazilDepartment of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, BrazilRegenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, BrazilMedical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, BrazilMedical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, BrazilDepartment of Locomotor Apparatus, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, BrazilMedical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, BrazilKnee osteoarthritis (OA) is a chronic articular disease characterized by the progressive degeneration of cartilage and bone tissue, leading to the appearance of subchondral cysts, osteophyte formation, and synovial inflammation. Conventional treatments consist of non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, and glucocorticoids. However, the prolonged use of these drugs causes adverse effects. NSAIDs, for instance, are known to be nephrotoxic, increasing the damage to articular cartilage. New therapies capable of accelerating the process of tissue regeneration and repair are being discussed, such as the use of orthobiologics that are naturally found in the body and obtained through minimally invasive collection and/or laboratory manipulations. Bone marrow aspirate (BMA) and bone marrow aspirate concentrate (BMAC) are both rich in hematopoietic stem cells, mesenchymal stem cells (MSCs), and growth factors (GFs) that can be used in the healing process due to their anabolic and anti-inflammatory effects. The aim of this literature review is to assess the efficacy of BMA and BMAC in the treatment of knee OA based on the favorable results that researchers have obtained with the use of both orthobiologics envisaging an accelerated healing process and the prevention of OA progression.https://www.mdpi.com/2227-9059/12/12/2812knee osteoarthritisbone marrow aspiratebone marrow aspirate concentratestem cellsregenerative medicine |
| spellingShingle | José Fábio Lana Joseph Purita Madhan Jeyaraman Bianca Freitas de Souza Bruno Lima Rodrigues Stephany Cares Huber Carolina Caliari Gabriel Silva Santos Lucas Furtado da Fonseca Ignacio Dallo Annu Navani Marco Antônio Percope De Andrade Peter Albert Everts Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products Biomedicines knee osteoarthritis bone marrow aspirate bone marrow aspirate concentrate stem cells regenerative medicine |
| title | Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products |
| title_full | Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products |
| title_fullStr | Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products |
| title_full_unstemmed | Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products |
| title_short | Innovative Approaches in Knee Osteoarthritis Treatment: A Comprehensive Review of Bone Marrow-Derived Products |
| title_sort | innovative approaches in knee osteoarthritis treatment a comprehensive review of bone marrow derived products |
| topic | knee osteoarthritis bone marrow aspirate bone marrow aspirate concentrate stem cells regenerative medicine |
| url | https://www.mdpi.com/2227-9059/12/12/2812 |
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