Use of plerixafor for hematopoietic stem cells mobilization in allograft donors
Unsuccessful mobilization of hematopoietic stem cells (HSCs) before apheresis in allograft donor is a factor adversely affecting the characteristics of the obtained cell product and, as a consequence, the therapy outcome. This study investigates the efficacy and safety of plerixafor as an additional...
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| Language: | Russian |
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ABV-press
2015-01-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/128 |
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| author | D. N. Balashov E. E. Kurnikova M. A. Maschan Yu. V. Skvortsov L. N. Shelikhova P. E. Trakhtman E. V. Boyakova E. V. Skorobogatova G. A. Novichkova A. A. Maschan |
| author_facet | D. N. Balashov E. E. Kurnikova M. A. Maschan Yu. V. Skvortsov L. N. Shelikhova P. E. Trakhtman E. V. Boyakova E. V. Skorobogatova G. A. Novichkova A. A. Maschan |
| author_sort | D. N. Balashov |
| collection | DOAJ |
| description | Unsuccessful mobilization of hematopoietic stem cells (HSCs) before apheresis in allograft donor is a factor adversely affecting the characteristics of the obtained cell product and, as a consequence, the therapy outcome. This study investigates the efficacy and safety of plerixafor as an additional alternative drug for HSCs mobilization after nsuccessful mobilization using G-CSF. Mobilization of HSC in all cases was performed using a preparation of G-CSF during 5 days. The ineffectiveness of this in 17 donors was revealed on the fourth day from the beginning of the mobilization, and therefore plerixafor was administered to all donors in this cohort 11–12 hours before cytapheresis. Use of plerixafor allowed obtaining a transplant with good cellular characteristics in all cases. Plerixafor safety profile comparable with GCSF has also been demonstrated. Based on the results of this study it was concluded about efficacy and feasibility of plerixafor as “rescue” therapy after unsuccessful mobilizationwith G-CSF. |
| format | Article |
| id | doaj-art-eb048bfbe2334fa0a8dda0102c794539 |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2015-01-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-eb048bfbe2334fa0a8dda0102c7945392025-08-20T03:35:33ZrusABV-pressОнкогематология1818-83462413-40232015-01-0194242710.17650/1818-8346-2014-9-4-560-578143Use of plerixafor for hematopoietic stem cells mobilization in allograft donorsD. N. Balashov0E. E. Kurnikova1M. A. Maschan2Yu. V. Skvortsov3L. N. Shelikhova4P. E. Trakhtman5E. V. Boyakova6E. V. Skorobogatova7G. A. Novichkova8A. A. Maschan9Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Russian Children’s Clinical Hospital, Ministry of Health of Russia, Moscow; 117, Leninskiy ave., Moscow, Russia, 117513Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Unsuccessful mobilization of hematopoietic stem cells (HSCs) before apheresis in allograft donor is a factor adversely affecting the characteristics of the obtained cell product and, as a consequence, the therapy outcome. This study investigates the efficacy and safety of plerixafor as an additional alternative drug for HSCs mobilization after nsuccessful mobilization using G-CSF. Mobilization of HSC in all cases was performed using a preparation of G-CSF during 5 days. The ineffectiveness of this in 17 donors was revealed on the fourth day from the beginning of the mobilization, and therefore plerixafor was administered to all donors in this cohort 11–12 hours before cytapheresis. Use of plerixafor allowed obtaining a transplant with good cellular characteristics in all cases. Plerixafor safety profile comparable with GCSF has also been demonstrated. Based on the results of this study it was concluded about efficacy and feasibility of plerixafor as “rescue” therapy after unsuccessful mobilizationwith G-CSF.https://oncohematology.abvpress.ru/ongm/article/view/128plerixaforg-csfallogeneic transplantationhematopoietic stem cellsmobilizationalternative technologydonorsapheresisefficacysafetyside effects |
| spellingShingle | D. N. Balashov E. E. Kurnikova M. A. Maschan Yu. V. Skvortsov L. N. Shelikhova P. E. Trakhtman E. V. Boyakova E. V. Skorobogatova G. A. Novichkova A. A. Maschan Use of plerixafor for hematopoietic stem cells mobilization in allograft donors Онкогематология plerixafor g-csf allogeneic transplantation hematopoietic stem cells mobilization alternative technology donors apheresis efficacy safety side effects |
| title | Use of plerixafor for hematopoietic stem cells mobilization in allograft donors |
| title_full | Use of plerixafor for hematopoietic stem cells mobilization in allograft donors |
| title_fullStr | Use of plerixafor for hematopoietic stem cells mobilization in allograft donors |
| title_full_unstemmed | Use of plerixafor for hematopoietic stem cells mobilization in allograft donors |
| title_short | Use of plerixafor for hematopoietic stem cells mobilization in allograft donors |
| title_sort | use of plerixafor for hematopoietic stem cells mobilization in allograft donors |
| topic | plerixafor g-csf allogeneic transplantation hematopoietic stem cells mobilization alternative technology donors apheresis efficacy safety side effects |
| url | https://oncohematology.abvpress.ru/ongm/article/view/128 |
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