Silk Fibroin Nanoparticles for Enhanced Cuproptosis and Immunotherapy in Pancreatic Cancer Treatment

Silk Fibroin Nanoparticles for Enhanced Cuproptosis and Immunotherapy in Pancreatic Cancer Treatment

Abstract Cuproptosis is a newly discovered copper ion‐dependent programmed cell death. Elesclomol (ES) is a Cu2+ transporter that delivers Cu2+ into tumor cells, causing cell death at toxic doses. However, ES has a short blood half‐life, limiting its accumulation in tumors. This study introduces Tus...

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Bibliographic Details
Main Authors: Si Gao, Haodong Ge, Lili Gao, Ying Gao, Shuibin Tang, Yiming Li, Zhiqing Yuan, Wei Chen
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
cancer therapy
cuproptosis
elesclomol
silk fibroin
αPDL‐1
Online Access:https://doi.org/10.1002/advs.202417676
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