MicroRNA-dependent mechanisms of taxane resistance in breast cancer
Breast cancer (BC) has a leading position in the statistics of oncological morbidity and mortality among women. Taxan-based polychemotherapy regimens are an essential component of the complex therapy of the BC. However, currently used algorithms of taxan-based regimens application do not always prov...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-12-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/996 |
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| author | V. S. Apollonova E. I. Sidina E. V. Tkachenko A. V. Malek |
| author_facet | V. S. Apollonova E. I. Sidina E. V. Tkachenko A. V. Malek |
| author_sort | V. S. Apollonova |
| collection | DOAJ |
| description | Breast cancer (BC) has a leading position in the statistics of oncological morbidity and mortality among women. Taxan-based polychemotherapy regimens are an essential component of the complex therapy of the BC. However, currently used algorithms of taxan-based regimens application do not always provide with desire effect. It indicates the need to identify new prognostic markers and to develop new approaches to modify response of BC cells to standard therapeutic regimens. MicroRNAs, small RNA molecules regulating protein synthesis, are considered as promising markers and potential modulators of the BC cells sensitivity to taxanes.The review includes a brief summary of the molecular mechanisms of action of the taxanes and the mechanism BC resistance to the process of microtubules depolymerization, provides with analysis of recent experimental and observational studies of the role of microRNAs in control of these mechanisms, and evaluates prospects for the development of new approaches to predict and to improve the cytostatic effects of taxanes through the analysis and modification of cellular microRNAs. |
| format | Article |
| id | doaj-art-eafc0755b4fd42c085d2811fdd64c835 |
| institution | DOAJ |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-eafc0755b4fd42c085d2811fdd64c8352025-08-20T03:01:59ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272022-12-01183526310.17650/1994-4098-2022-18-3-52-63749MicroRNA-dependent mechanisms of taxane resistance in breast cancerV. S. Apollonova0E. I. Sidina1E. V. Tkachenko2A. V. Malek3N. N. Petrov National Medical Research Center of Oncology, Ministry of Health of RussiaN. N. Petrov National Medical Research Center of Oncology, Ministry of Health of RussiaN. N. Petrov National Medical Research Center of Oncology, Ministry of Health of RussiaN. N. Petrov National Medical Research Center of Oncology, Ministry of Health of RussiaBreast cancer (BC) has a leading position in the statistics of oncological morbidity and mortality among women. Taxan-based polychemotherapy regimens are an essential component of the complex therapy of the BC. However, currently used algorithms of taxan-based regimens application do not always provide with desire effect. It indicates the need to identify new prognostic markers and to develop new approaches to modify response of BC cells to standard therapeutic regimens. MicroRNAs, small RNA molecules regulating protein synthesis, are considered as promising markers and potential modulators of the BC cells sensitivity to taxanes.The review includes a brief summary of the molecular mechanisms of action of the taxanes and the mechanism BC resistance to the process of microtubules depolymerization, provides with analysis of recent experimental and observational studies of the role of microRNAs in control of these mechanisms, and evaluates prospects for the development of new approaches to predict and to improve the cytostatic effects of taxanes through the analysis and modification of cellular microRNAs.https://ojrs.abvpress.ru/ojrs/article/view/996micrornataxanepaclitaxeltubulinmicrotubulesmirna mimicantimirs |
| spellingShingle | V. S. Apollonova E. I. Sidina E. V. Tkachenko A. V. Malek MicroRNA-dependent mechanisms of taxane resistance in breast cancer Опухоли женской репродуктивной системы microrna taxane paclitaxel tubulin microtubules mirna mimic antimirs |
| title | MicroRNA-dependent mechanisms of taxane resistance in breast cancer |
| title_full | MicroRNA-dependent mechanisms of taxane resistance in breast cancer |
| title_fullStr | MicroRNA-dependent mechanisms of taxane resistance in breast cancer |
| title_full_unstemmed | MicroRNA-dependent mechanisms of taxane resistance in breast cancer |
| title_short | MicroRNA-dependent mechanisms of taxane resistance in breast cancer |
| title_sort | microrna dependent mechanisms of taxane resistance in breast cancer |
| topic | microrna taxane paclitaxel tubulin microtubules mirna mimic antimirs |
| url | https://ojrs.abvpress.ru/ojrs/article/view/996 |
| work_keys_str_mv | AT vsapollonova micrornadependentmechanismsoftaxaneresistanceinbreastcancer AT eisidina micrornadependentmechanismsoftaxaneresistanceinbreastcancer AT evtkachenko micrornadependentmechanismsoftaxaneresistanceinbreastcancer AT avmalek micrornadependentmechanismsoftaxaneresistanceinbreastcancer |