Lithium-Associated Kidney Microcysts
Long-term lithium therapy is associated with impairment in concentrating ability and, occasionally, progression to advanced chronic kidney disease from tubulointerstitial nephropathy. Biopsy findings in patients with lithium-induced chronic tubulointerstitial nephropathy include tubular atrophy and...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2008.112 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850164231459045376 |
|---|---|
| author | Jennifer Tuazon David Casalino Ehteshamuddin Syed Daniel Batlle |
| author_facet | Jennifer Tuazon David Casalino Ehteshamuddin Syed Daniel Batlle |
| author_sort | Jennifer Tuazon |
| collection | DOAJ |
| description | Long-term lithium therapy is associated with impairment in concentrating ability and, occasionally, progression to advanced chronic kidney disease from tubulointerstitial nephropathy. Biopsy findings in patients with lithium-induced chronic tubulointerstitial nephropathy include tubular atrophy and interstitial fibrosis interspersed with tubular cysts and dilatations. Recent studies have shown that cysts are seen in 33–62.5% of the patients undergoing lithium therapy. MR imaging is highly capable of defining renal morphological features and has been demonstrated to be superior to US and CT scan for the visualization of small renal cysts. The microcysts are found in both cortex and medulla, particularly in the regions with extensive atrophy and fibrosis, and can be multiple and bilateral. They tend to be sparse and do not normally exceed 12 mm in diameter. The renal microcysts in the image here reported are subtle, but consistent with lithium-induced chronic nephropathy. An MRI of the kidneys provides noninvasive evidence that strengthens the diagnosis of lithium-induced nephropathy. |
| format | Article |
| id | doaj-art-eaf8fd0c7cd746819bf2e0861fc0f880 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-eaf8fd0c7cd746819bf2e0861fc0f8802025-08-20T02:22:02ZengWileyThe Scientific World Journal1537-744X2008-01-01882882910.1100/tsw.2008.112Lithium-Associated Kidney MicrocystsJennifer Tuazon0David Casalino1Ehteshamuddin Syed2Daniel Batlle3Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, USADivision of Radiology Northwestern, University Feinberg School of Medicine, Chicago, USADivision of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, USADivision of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, USALong-term lithium therapy is associated with impairment in concentrating ability and, occasionally, progression to advanced chronic kidney disease from tubulointerstitial nephropathy. Biopsy findings in patients with lithium-induced chronic tubulointerstitial nephropathy include tubular atrophy and interstitial fibrosis interspersed with tubular cysts and dilatations. Recent studies have shown that cysts are seen in 33–62.5% of the patients undergoing lithium therapy. MR imaging is highly capable of defining renal morphological features and has been demonstrated to be superior to US and CT scan for the visualization of small renal cysts. The microcysts are found in both cortex and medulla, particularly in the regions with extensive atrophy and fibrosis, and can be multiple and bilateral. They tend to be sparse and do not normally exceed 12 mm in diameter. The renal microcysts in the image here reported are subtle, but consistent with lithium-induced chronic nephropathy. An MRI of the kidneys provides noninvasive evidence that strengthens the diagnosis of lithium-induced nephropathy.http://dx.doi.org/10.1100/tsw.2008.112 |
| spellingShingle | Jennifer Tuazon David Casalino Ehteshamuddin Syed Daniel Batlle Lithium-Associated Kidney Microcysts The Scientific World Journal |
| title | Lithium-Associated Kidney Microcysts |
| title_full | Lithium-Associated Kidney Microcysts |
| title_fullStr | Lithium-Associated Kidney Microcysts |
| title_full_unstemmed | Lithium-Associated Kidney Microcysts |
| title_short | Lithium-Associated Kidney Microcysts |
| title_sort | lithium associated kidney microcysts |
| url | http://dx.doi.org/10.1100/tsw.2008.112 |
| work_keys_str_mv | AT jennifertuazon lithiumassociatedkidneymicrocysts AT davidcasalino lithiumassociatedkidneymicrocysts AT ehteshamuddinsyed lithiumassociatedkidneymicrocysts AT danielbatlle lithiumassociatedkidneymicrocysts |