Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells.

Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells.

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Parasitic infections are a major worldwide health burden, yet most studies of CD8 T cell differentiation focus on acute viral and bacterial infections. To understand effector and memory CD8 T cell responses during erythrocytic malaria infection in mice, we utilized transgenic OT-I T cells and compar...

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Bibliographic Details
Main Authors: Jacob A Hildebrand, Noah R Daniels, Emma M Dehm, Benjamin D Fisher, Joseph K Guter, Chris J Janse, Erin D Lucas, Jules A Sangala, Trevor N Tankersley, Geoffrey T Hart, Sara E Hamilton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012993
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