Reinforcing the aneurysmal aorta by additional layering: old and new strategies to prevent rupture
Adventitial crosslinking is a method in current investigational stage for preventing the rupture of aortic aneurysms. It is based on the photochemical crosslinking of adventitial collagen by exposure to ultraviolet A radiation. Essentially, an adventitial top layer is generated that displays enhance...
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| Language: | English |
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Open Exploration Publishing Inc.
2024-06-01
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| Series: | Exploration of Cardiology |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A101227/101227.pdf |
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| author | Traian V. Chirila |
| author_facet | Traian V. Chirila |
| author_sort | Traian V. Chirila |
| collection | DOAJ |
| description | Adventitial crosslinking is a method in current investigational stage for preventing the rupture of aortic aneurysms. It is based on the photochemical crosslinking of adventitial collagen by exposure to ultraviolet A radiation. Essentially, an adventitial top layer is generated that displays enhanced mechanical properties and imparts additional strength and stiffness to the aneurysmal wall. Looking back upon the history of aortic surgery during 1940s, the aortic film wrapping, then dubbed “cellophane wrapping”, also was a procedure employed for delaying the aneurysmal rupture. In principle, the two procedures are similar in that both result in laminar composites, although the top layers differ fundamentally from each other. This review discussed in some detail the use and clinical outcomes of the aortic wrapping with artificial films, also mentioning the contemporary procedures still grouped under this umbrella term. The focus of the review was a comparative view on two procedures, the aortic film wrapping and adventitial crosslinking. It was concluded that the methods are different in many aspects, including the mechanisms of action. In fact, the promoters of adventitial crosslinking were not aware of the prior existence of aortic film wrapping. However, the achievements of the classical wrapping, by now regarded as merely historical episodes, did not discard prior knowledge, but repurposed it in a process that led to innovative strategies. |
| format | Article |
| id | doaj-art-eaf51c81bc87402c94006869aef94c75 |
| institution | DOAJ |
| issn | 2994-5526 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Cardiology |
| spelling | doaj-art-eaf51c81bc87402c94006869aef94c752025-08-20T03:12:27ZengOpen Exploration Publishing Inc.Exploration of Cardiology2994-55262024-06-012313414710.37349/ec.2024.00027Reinforcing the aneurysmal aorta by additional layering: old and new strategies to prevent ruptureTraian V. Chirila0https://orcid.org/0000-0001-6278-3168Queensland Eye Institute, Woolloongabba, Queensland 4102, Australia; School of Chemistry and Physics, Queensland University of Technology, Brisbane, Queensland 4001, Australia; Australian Institute of Bioengineering and Nanotechnology (AIBN), University of Queensland, St Lucia, Queensland 4072, Australia; Centre for Advanced Medical and Pharmaceutical Research (CCAMF), George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540139 Targu Mures, Romania; Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540139 Targu Mures, RomaniaAdventitial crosslinking is a method in current investigational stage for preventing the rupture of aortic aneurysms. It is based on the photochemical crosslinking of adventitial collagen by exposure to ultraviolet A radiation. Essentially, an adventitial top layer is generated that displays enhanced mechanical properties and imparts additional strength and stiffness to the aneurysmal wall. Looking back upon the history of aortic surgery during 1940s, the aortic film wrapping, then dubbed “cellophane wrapping”, also was a procedure employed for delaying the aneurysmal rupture. In principle, the two procedures are similar in that both result in laminar composites, although the top layers differ fundamentally from each other. This review discussed in some detail the use and clinical outcomes of the aortic wrapping with artificial films, also mentioning the contemporary procedures still grouped under this umbrella term. The focus of the review was a comparative view on two procedures, the aortic film wrapping and adventitial crosslinking. It was concluded that the methods are different in many aspects, including the mechanisms of action. In fact, the promoters of adventitial crosslinking were not aware of the prior existence of aortic film wrapping. However, the achievements of the classical wrapping, by now regarded as merely historical episodes, did not discard prior knowledge, but repurposed it in a process that led to innovative strategies.https://www.explorationpub.com/uploads/Article/A101227/101227.pdfaortic aneurysmswrapping proceduresfilmcellophanepolyethyleneexternal reinforcingadventitial crosslinking |
| spellingShingle | Traian V. Chirila Reinforcing the aneurysmal aorta by additional layering: old and new strategies to prevent rupture Exploration of Cardiology aortic aneurysms wrapping procedures film cellophane polyethylene external reinforcing adventitial crosslinking |
| title | Reinforcing the aneurysmal aorta by additional layering: old and new strategies to prevent rupture |
| title_full | Reinforcing the aneurysmal aorta by additional layering: old and new strategies to prevent rupture |
| title_fullStr | Reinforcing the aneurysmal aorta by additional layering: old and new strategies to prevent rupture |
| title_full_unstemmed | Reinforcing the aneurysmal aorta by additional layering: old and new strategies to prevent rupture |
| title_short | Reinforcing the aneurysmal aorta by additional layering: old and new strategies to prevent rupture |
| title_sort | reinforcing the aneurysmal aorta by additional layering old and new strategies to prevent rupture |
| topic | aortic aneurysms wrapping procedures film cellophane polyethylene external reinforcing adventitial crosslinking |
| url | https://www.explorationpub.com/uploads/Article/A101227/101227.pdf |
| work_keys_str_mv | AT traianvchirila reinforcingtheaneurysmalaortabyadditionallayeringoldandnewstrategiestopreventrupture |