Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is an aggressive, invasive malignancy of epithelial origin. The progression from premalignant lesions—oral leukoplakia (OLK) and oral lichen planus (OLP)—to OSCC involves complex inflammatory processes that have not been elucidated. We investigated the roles of in...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/5715719 |
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| author | Yujuan Sun Nan Liu Xiaobing Guan Hongru Wu Zheng Sun Hui Zeng |
| author_facet | Yujuan Sun Nan Liu Xiaobing Guan Hongru Wu Zheng Sun Hui Zeng |
| author_sort | Yujuan Sun |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is an aggressive, invasive malignancy of epithelial origin. The progression from premalignant lesions—oral leukoplakia (OLK) and oral lichen planus (OLP)—to OSCC involves complex inflammatory processes that have not been elucidated. We investigated the roles of inflammatory mediators and infiltrating immunocytes in the pathogenic progression of OLK and OLP to OSCC. The occurrence of regulatory T-cells (Tregs) and tumor-associated macrophages (TAMs) and the expression of anti-inflammatory cytokines and proinflammatory cytokines were investigated in OLK, OLP, and OSCC tissues. Immunohistochemical staining of CD4, FOXP3, CD68, TGF-β1, IL-10, IL-4, IFN-γ, and MCP-1 showed that the occurrence of Tregs and TAMs increased in parallel with disease progression in OLK and OSCC. IL-10 gradually increased during the early stages of OLK and in OSCC. Infiltrating IL-4+ macrophages were seen with increasing frequency in OLK tissue during the progression of oral dysplasia. Fewer TGF-β1+ macrophages were seen in OSCC than in OLK and OLP. The expression of IFN-γ decreased gradually with the OLK development and had the lowest expression in OSCC. MCP-1 expression did not change significantly during the development of OSCC. The results suggested that the immunosuppression induced by chronic inflammation promotes tumorigenesis in OSCC, rather than initiating it. |
| format | Article |
| id | doaj-art-eaf4287852164b918263e622df644c70 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-eaf4287852164b918263e622df644c702025-02-03T01:31:47ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/57157195715719Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell CarcinomaYujuan Sun0Nan Liu1Xiaobing Guan2Hongru Wu3Zheng Sun4Hui Zeng5Department of Periodontal & Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Stomatology, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, ChinaDepartment of Periodontal & Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Periodontal & Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Periodontal & Oral Medicine, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, ChinaInstitute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, ChinaOral squamous cell carcinoma (OSCC) is an aggressive, invasive malignancy of epithelial origin. The progression from premalignant lesions—oral leukoplakia (OLK) and oral lichen planus (OLP)—to OSCC involves complex inflammatory processes that have not been elucidated. We investigated the roles of inflammatory mediators and infiltrating immunocytes in the pathogenic progression of OLK and OLP to OSCC. The occurrence of regulatory T-cells (Tregs) and tumor-associated macrophages (TAMs) and the expression of anti-inflammatory cytokines and proinflammatory cytokines were investigated in OLK, OLP, and OSCC tissues. Immunohistochemical staining of CD4, FOXP3, CD68, TGF-β1, IL-10, IL-4, IFN-γ, and MCP-1 showed that the occurrence of Tregs and TAMs increased in parallel with disease progression in OLK and OSCC. IL-10 gradually increased during the early stages of OLK and in OSCC. Infiltrating IL-4+ macrophages were seen with increasing frequency in OLK tissue during the progression of oral dysplasia. Fewer TGF-β1+ macrophages were seen in OSCC than in OLK and OLP. The expression of IFN-γ decreased gradually with the OLK development and had the lowest expression in OSCC. MCP-1 expression did not change significantly during the development of OSCC. The results suggested that the immunosuppression induced by chronic inflammation promotes tumorigenesis in OSCC, rather than initiating it.http://dx.doi.org/10.1155/2016/5715719 |
| spellingShingle | Yujuan Sun Nan Liu Xiaobing Guan Hongru Wu Zheng Sun Hui Zeng Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma Mediators of Inflammation |
| title | Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma |
| title_full | Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma |
| title_fullStr | Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma |
| title_short | Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma |
| title_sort | immunosuppression induced by chronic inflammation and the progression to oral squamous cell carcinoma |
| url | http://dx.doi.org/10.1155/2016/5715719 |
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