Retargeting of Viruses to Generate Oncolytic Agents
Oncolytic virus therapy is based on the ability of viruses to effectively infect and kill tumor cells without destroying the normal tissues. While some viruses seem to have a natural preference for tumor cells, most viruses require the modification of their tropism to specifically enter and replicat...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2012/798526 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849690186379689984 |
|---|---|
| author | M. H. Verheije P. J. M. Rottier |
| author_facet | M. H. Verheije P. J. M. Rottier |
| author_sort | M. H. Verheije |
| collection | DOAJ |
| description | Oncolytic virus therapy is based on the ability of viruses to effectively infect and kill tumor cells without destroying the normal tissues. While some viruses seem to have a natural preference for tumor cells, most viruses require the modification of their tropism to specifically enter and replicate in such cells. This review aims to describe the transductional targeting strategies currently employed to specifically redirect viruses towards surface receptors on tumor cells. Three major strategies can be distinguished; they involve (i) the incorporation of new targeting specificity into a viral surface protein, (ii) the incorporation of a scaffold into a viral surface protein to allow the attachment of targeting moieties, and (iii) the use of bispecific adapters to mediate targeting of a virus to a specified moiety on a tumor cell. Of each strategy key features, advantages and limitations are discussed and examples are given. Because of their potential to cause sustained, multiround infection—a desirable characteristic for eradicating tumors—particular attention is given to viruses engineered to become self-targeted by the genomic expression of a bispecific adapter protein. |
| format | Article |
| id | doaj-art-eaf26a9c9df840e497e68d066e6827fb |
| institution | DOAJ |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-eaf26a9c9df840e497e68d066e6827fb2025-08-20T03:21:23ZengWileyAdvances in Virology1687-86391687-86472012-01-01201210.1155/2012/798526798526Retargeting of Viruses to Generate Oncolytic AgentsM. H. Verheije0P. J. M. Rottier1Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The NetherlandsVirology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The NetherlandsOncolytic virus therapy is based on the ability of viruses to effectively infect and kill tumor cells without destroying the normal tissues. While some viruses seem to have a natural preference for tumor cells, most viruses require the modification of their tropism to specifically enter and replicate in such cells. This review aims to describe the transductional targeting strategies currently employed to specifically redirect viruses towards surface receptors on tumor cells. Three major strategies can be distinguished; they involve (i) the incorporation of new targeting specificity into a viral surface protein, (ii) the incorporation of a scaffold into a viral surface protein to allow the attachment of targeting moieties, and (iii) the use of bispecific adapters to mediate targeting of a virus to a specified moiety on a tumor cell. Of each strategy key features, advantages and limitations are discussed and examples are given. Because of their potential to cause sustained, multiround infection—a desirable characteristic for eradicating tumors—particular attention is given to viruses engineered to become self-targeted by the genomic expression of a bispecific adapter protein.http://dx.doi.org/10.1155/2012/798526 |
| spellingShingle | M. H. Verheije P. J. M. Rottier Retargeting of Viruses to Generate Oncolytic Agents Advances in Virology |
| title | Retargeting of Viruses to Generate Oncolytic Agents |
| title_full | Retargeting of Viruses to Generate Oncolytic Agents |
| title_fullStr | Retargeting of Viruses to Generate Oncolytic Agents |
| title_full_unstemmed | Retargeting of Viruses to Generate Oncolytic Agents |
| title_short | Retargeting of Viruses to Generate Oncolytic Agents |
| title_sort | retargeting of viruses to generate oncolytic agents |
| url | http://dx.doi.org/10.1155/2012/798526 |
| work_keys_str_mv | AT mhverheije retargetingofvirusestogenerateoncolyticagents AT pjmrottier retargetingofvirusestogenerateoncolyticagents |