Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma: a retrospective study from Japan
Background/Aims Biliary obstruction drainage in patients with hepatocellular carcinoma (HCC) is associated with symptom palliation, improved access to chemotherapy, and improved survival. Stent placement and exchange via endoscopic retrograde cholangiopancreatography biliary drainage risk traversing...
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Korean Society of Gastrointestinal Endoscopy
2025-05-01
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| Series: | Clinical Endoscopy |
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| Online Access: | http://e-ce.org/upload/pdf/ce-2024-079.pdf |
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| author | Kenneth Tachi Kazuo Hara Nozomi Okuno Shin Haba Takamichi Kuwahara Toshitaka Fukui Ahmed Mohammed Sadek Hossam El-Din Shaaban Mahmoud Ibrahim Minako Urata Takashi Kondo Yoshitaro Yamamoto |
| author_facet | Kenneth Tachi Kazuo Hara Nozomi Okuno Shin Haba Takamichi Kuwahara Toshitaka Fukui Ahmed Mohammed Sadek Hossam El-Din Shaaban Mahmoud Ibrahim Minako Urata Takashi Kondo Yoshitaro Yamamoto |
| author_sort | Kenneth Tachi |
| collection | DOAJ |
| description | Background/Aims Biliary obstruction drainage in patients with hepatocellular carcinoma (HCC) is associated with symptom palliation, improved access to chemotherapy, and improved survival. Stent placement and exchange via endoscopic retrograde cholangiopancreatography biliary drainage risk traversing the HCC, a hypervascular tumor and causing bleeding. Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) potentially prevents procedure-related bleeding. Therefore, we evaluated the efficacy and safety of EUS-HGS as an alternative treatment for biliary obstruction in patients with HCC. Methods This was a retrospective study of all EUS-HGS procedures performed in patients with HCC at the Aichi Cancer Center Hospital, Japan, from February 2017 to August 2023. Results A total of 14 EUS-HGS procedures (42.9% primary) were attempted in 10 HCC patients (mean age 71.5 years, 80.0% male). Clinical and technical success rates were 92.9% and 90.9%, respectively. The observed procedure details in the 13 successful procedures included B3 puncture (53.8%), 22-G needle (53.8%), fully covered self-expandable metal stent (100%), and mean procedure time (32.7 minutes). There was no bleeding. Mild complications occurred in 27.3%. All patients resumed oral intake within 24 hours. Conclusions EUS-HGS is a technically feasible and clinically effective initial or salvage drainage option for the treatment of biliary obstruction in patients with HCC. |
| format | Article |
| id | doaj-art-eaf195864c824a30a0aea6468f4ce7de |
| institution | Kabale University |
| issn | 2234-2400 2234-2443 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj-art-eaf195864c824a30a0aea6468f4ce7de2025-08-20T03:33:25ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432025-05-0158344845610.5946/ce.2024.0797940Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma: a retrospective study from JapanKenneth TachiKazuo HaraNozomi OkunoShin HabaTakamichi KuwaharaToshitaka FukuiAhmed Mohammed SadekHossam El-Din Shaaban Mahmoud IbrahimMinako UrataTakashi KondoYoshitaro YamamotoBackground/Aims Biliary obstruction drainage in patients with hepatocellular carcinoma (HCC) is associated with symptom palliation, improved access to chemotherapy, and improved survival. Stent placement and exchange via endoscopic retrograde cholangiopancreatography biliary drainage risk traversing the HCC, a hypervascular tumor and causing bleeding. Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) potentially prevents procedure-related bleeding. Therefore, we evaluated the efficacy and safety of EUS-HGS as an alternative treatment for biliary obstruction in patients with HCC. Methods This was a retrospective study of all EUS-HGS procedures performed in patients with HCC at the Aichi Cancer Center Hospital, Japan, from February 2017 to August 2023. Results A total of 14 EUS-HGS procedures (42.9% primary) were attempted in 10 HCC patients (mean age 71.5 years, 80.0% male). Clinical and technical success rates were 92.9% and 90.9%, respectively. The observed procedure details in the 13 successful procedures included B3 puncture (53.8%), 22-G needle (53.8%), fully covered self-expandable metal stent (100%), and mean procedure time (32.7 minutes). There was no bleeding. Mild complications occurred in 27.3%. All patients resumed oral intake within 24 hours. Conclusions EUS-HGS is a technically feasible and clinically effective initial or salvage drainage option for the treatment of biliary obstruction in patients with HCC.http://e-ce.org/upload/pdf/ce-2024-079.pdfcholangitisendosonographyfibrosishepatocellular carcinomaobstructive jaundice |
| spellingShingle | Kenneth Tachi Kazuo Hara Nozomi Okuno Shin Haba Takamichi Kuwahara Toshitaka Fukui Ahmed Mohammed Sadek Hossam El-Din Shaaban Mahmoud Ibrahim Minako Urata Takashi Kondo Yoshitaro Yamamoto Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma: a retrospective study from Japan Clinical Endoscopy cholangitis endosonography fibrosis hepatocellular carcinoma obstructive jaundice |
| title | Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma: a retrospective study from Japan |
| title_full | Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma: a retrospective study from Japan |
| title_fullStr | Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma: a retrospective study from Japan |
| title_full_unstemmed | Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma: a retrospective study from Japan |
| title_short | Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma: a retrospective study from Japan |
| title_sort | efficacy and safety of endoscopic ultrasound guided hepaticogastrostomy for biliary drainage in hypervascular hepatocellular carcinoma a retrospective study from japan |
| topic | cholangitis endosonography fibrosis hepatocellular carcinoma obstructive jaundice |
| url | http://e-ce.org/upload/pdf/ce-2024-079.pdf |
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