Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
Cardiovascular disease (CVD) is one of the most severe diseases in clinics. Fibroblast growth factor 21 (FGF21) is regarded as an important metabolic regulator playing a therapeutic role in diabetes and its complications. The heart is a key target as well as a source of FGF21 which is involved in he...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/1540267 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849690185938239488 |
|---|---|
| author | Peng Cheng Fangfang Zhang Lechu Yu Xiufei Lin Luqing He Xiaokun Li Xuemian Lu Xiaoqing Yan Yi Tan Chi Zhang |
| author_facet | Peng Cheng Fangfang Zhang Lechu Yu Xiufei Lin Luqing He Xiaokun Li Xuemian Lu Xiaoqing Yan Yi Tan Chi Zhang |
| author_sort | Peng Cheng |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is one of the most severe diseases in clinics. Fibroblast growth factor 21 (FGF21) is regarded as an important metabolic regulator playing a therapeutic role in diabetes and its complications. The heart is a key target as well as a source of FGF21 which is involved in heart development and also induces beneficial effects in CVDs. Our review is to clarify the roles of FGF21 in CVDs. Strong evidence showed that the development of CVDs including atherosclerosis, coronary heart disease, myocardial ischemia, cardiac hypertrophy, and diabetic cardiomyopathy is associated with serum FGF21 levels increase which was regarded as a compensatory response to induced cardiac protection. Furthermore, administration of FGF21 suppressed the above CVDs. Mechanistic studies revealed that FGF21 induced cardiac protection likely by preventing cardiac lipotoxicity and the associated oxidative stress, inflammation, and apoptosis. Normally, FGF21 induced therapeutic effects against CVDs via activation of the above kinases-mediated pathways by directly binding to the FGF receptors of the heart in the presence of β-klotho. However, recently, growing evidence showed that FGF21 induced beneficial effects on peripheral organs through an indirect way mediated by adiponectin. Therefore whether adiponectin is also involved in FGF21-induced cardiac protection still needs further investigation. |
| format | Article |
| id | doaj-art-eaf169dce07945c0a5f80f16e311e63c |
| institution | DOAJ |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-eaf169dce07945c0a5f80f16e311e63c2025-08-20T03:21:23ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/15402671540267Physiological and Pharmacological Roles of FGF21 in Cardiovascular DiseasesPeng Cheng0Fangfang Zhang1Lechu Yu2Xiufei Lin3Luqing He4Xiaokun Li5Xuemian Lu6Xiaoqing Yan7Yi Tan8Chi Zhang9The Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, ChinaThe Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, ChinaThe Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, ChinaThe Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, ChinaThe Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, ChinaRuian Center of the Chinese-American Research Institute for Diabetic Complications, The Third Affiliated Hospital, Wenzhou Medical University, Wenzhou 325200, ChinaThe Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, ChinaThe Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, ChinaThe Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, ChinaThe Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou 325035, ChinaCardiovascular disease (CVD) is one of the most severe diseases in clinics. Fibroblast growth factor 21 (FGF21) is regarded as an important metabolic regulator playing a therapeutic role in diabetes and its complications. The heart is a key target as well as a source of FGF21 which is involved in heart development and also induces beneficial effects in CVDs. Our review is to clarify the roles of FGF21 in CVDs. Strong evidence showed that the development of CVDs including atherosclerosis, coronary heart disease, myocardial ischemia, cardiac hypertrophy, and diabetic cardiomyopathy is associated with serum FGF21 levels increase which was regarded as a compensatory response to induced cardiac protection. Furthermore, administration of FGF21 suppressed the above CVDs. Mechanistic studies revealed that FGF21 induced cardiac protection likely by preventing cardiac lipotoxicity and the associated oxidative stress, inflammation, and apoptosis. Normally, FGF21 induced therapeutic effects against CVDs via activation of the above kinases-mediated pathways by directly binding to the FGF receptors of the heart in the presence of β-klotho. However, recently, growing evidence showed that FGF21 induced beneficial effects on peripheral organs through an indirect way mediated by adiponectin. Therefore whether adiponectin is also involved in FGF21-induced cardiac protection still needs further investigation.http://dx.doi.org/10.1155/2016/1540267 |
| spellingShingle | Peng Cheng Fangfang Zhang Lechu Yu Xiufei Lin Luqing He Xiaokun Li Xuemian Lu Xiaoqing Yan Yi Tan Chi Zhang Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases Journal of Diabetes Research |
| title | Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases |
| title_full | Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases |
| title_fullStr | Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases |
| title_full_unstemmed | Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases |
| title_short | Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases |
| title_sort | physiological and pharmacological roles of fgf21 in cardiovascular diseases |
| url | http://dx.doi.org/10.1155/2016/1540267 |
| work_keys_str_mv | AT pengcheng physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases AT fangfangzhang physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases AT lechuyu physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases AT xiufeilin physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases AT luqinghe physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases AT xiaokunli physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases AT xuemianlu physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases AT xiaoqingyan physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases AT yitan physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases AT chizhang physiologicalandpharmacologicalrolesoffgf21incardiovasculardiseases |