Exploring the Relationship Between Personalization of Care and Participation in Sport Activities Among People with Severe Hemophilia A Across Europe: Post Hoc Analysis of the CHESS II Study
Tom Blenkiron,1 Enrico Ferri Grazzi,1 Tom Burke,1,2 Maureen Watt,3 Kimberly H Davis3 1HCD Economics Ltd, Daresbury, UK; 2Faculty of Social Care, University of Chester, Chester, UK; 3Takeda Development Center Americas, Inc, Cambridge, MA, USACorrespondence: Enrico Ferri Grazzi, HCD Economics, Mere Ho...
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Dove Medical Press
2025-08-01
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| author | Blenkiron T Ferri Grazzi E Burke T Watt M Davis KH |
| author_facet | Blenkiron T Ferri Grazzi E Burke T Watt M Davis KH |
| author_sort | Blenkiron T |
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| description | Tom Blenkiron,1 Enrico Ferri Grazzi,1 Tom Burke,1,2 Maureen Watt,3 Kimberly H Davis3 1HCD Economics Ltd, Daresbury, UK; 2Faculty of Social Care, University of Chester, Chester, UK; 3Takeda Development Center Americas, Inc, Cambridge, MA, USACorrespondence: Enrico Ferri Grazzi, HCD Economics, Mere House, Brook Street, Knutsford, Daresbury, WA16 8GP, UK, Tel +44 1925 606475, Email enrico.ferrigrazzi@primeglobalpeople.comPurpose: To describe the demographic and clinical characteristics of patients with hemophilia A receiving different levels of treatment personalization (TP), and to assess the relationship between TP and sport active time (SAT).Patients and Methods: This post hoc analysis of the CHESS II study used data from physician-completed patient record forms and patient self-completion forms for adult males receiving prophylaxis for severe hemophilia A in Europe between November 2018 and October 2020. SAT was assessed using propensity score matching (PSM) across levels of TP, including pharmacokinetic (PK)-guided and non-PK-guided.Results: Of 54 patients, 32 (59.3%) received TP. Of these, 22 (68.8%) and 10 (31.3%) received non-PK-guided and PK-guided treatment, respectively. Median age varied between the TP and no-TP groups (29.5 and 34.0 years, respectively). Median (IQR) annual bleeding incidence was higher with non-PK-guided vs PK-guided TP (4.0 [3.0– 8.0] vs 3.5 [2.0– 4.0]). Median (IQR) problem joints were similar with non-PK-guided and PK-guided TP (1.0 [0.0– 1.0] and 1.0 [0.0– 2.0]). Patients in the TP vs no-TP group had higher median (IQR) SAT per month (3.3 [1.8– 6.2] vs 1.8 [0.7– 5.0] hours). Median (IQR) SAT per month was higher with PK-guided vs non-PK-guided TP (4.0 [3.0– 20.0] vs 3.0 [1.3– 5.3] hours). After controlling for confounding in the PSM model, SAT remained higher with TP vs no-TP and with PK-guided vs non-PK-guided TP. In both PSM models, P values were < 0.05 for the average treatment effect and < 0.01 for the average treatment effect on the treated. Sensitivity analyses confirmed the robustness of the PSM.Conclusion: Patients receiving TP vs no-TP had higher median SAT. Of those with TP, those receiving PK-guided vs non-PK-guided TP experienced lower bleeding rates and higher SAT. PK-guided TP may help patients to be more active, potentially gaining the clinical and psychosocial benefits of exercise.Keywords: exercise, pharmacokinetic-guided treatment, prophylaxis, quality of life, treatment personalization, hemophilia A |
| format | Article |
| id | doaj-art-eae9da51929f4654a7c094aa8ff99b27 |
| institution | Kabale University |
| issn | 1179-2736 |
| language | English |
| publishDate | 2025-08-01 |
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| series | Journal of Blood Medicine |
| spelling | doaj-art-eae9da51929f4654a7c094aa8ff99b272025-08-20T03:41:11ZengDove Medical PressJournal of Blood Medicine1179-27362025-08-01Volume 16Issue 1359372105495Exploring the Relationship Between Personalization of Care and Participation in Sport Activities Among People with Severe Hemophilia A Across Europe: Post Hoc Analysis of the CHESS II StudyBlenkiron T0Ferri Grazzi E1Burke T2Watt M3Davis KH4DeliveryHEORHEORGlobal Outcomes ResearchGlobal Evidence & OutcomesTom Blenkiron,1 Enrico Ferri Grazzi,1 Tom Burke,1,2 Maureen Watt,3 Kimberly H Davis3 1HCD Economics Ltd, Daresbury, UK; 2Faculty of Social Care, University of Chester, Chester, UK; 3Takeda Development Center Americas, Inc, Cambridge, MA, USACorrespondence: Enrico Ferri Grazzi, HCD Economics, Mere House, Brook Street, Knutsford, Daresbury, WA16 8GP, UK, Tel +44 1925 606475, Email enrico.ferrigrazzi@primeglobalpeople.comPurpose: To describe the demographic and clinical characteristics of patients with hemophilia A receiving different levels of treatment personalization (TP), and to assess the relationship between TP and sport active time (SAT).Patients and Methods: This post hoc analysis of the CHESS II study used data from physician-completed patient record forms and patient self-completion forms for adult males receiving prophylaxis for severe hemophilia A in Europe between November 2018 and October 2020. SAT was assessed using propensity score matching (PSM) across levels of TP, including pharmacokinetic (PK)-guided and non-PK-guided.Results: Of 54 patients, 32 (59.3%) received TP. Of these, 22 (68.8%) and 10 (31.3%) received non-PK-guided and PK-guided treatment, respectively. Median age varied between the TP and no-TP groups (29.5 and 34.0 years, respectively). Median (IQR) annual bleeding incidence was higher with non-PK-guided vs PK-guided TP (4.0 [3.0– 8.0] vs 3.5 [2.0– 4.0]). Median (IQR) problem joints were similar with non-PK-guided and PK-guided TP (1.0 [0.0– 1.0] and 1.0 [0.0– 2.0]). Patients in the TP vs no-TP group had higher median (IQR) SAT per month (3.3 [1.8– 6.2] vs 1.8 [0.7– 5.0] hours). Median (IQR) SAT per month was higher with PK-guided vs non-PK-guided TP (4.0 [3.0– 20.0] vs 3.0 [1.3– 5.3] hours). After controlling for confounding in the PSM model, SAT remained higher with TP vs no-TP and with PK-guided vs non-PK-guided TP. In both PSM models, P values were < 0.05 for the average treatment effect and < 0.01 for the average treatment effect on the treated. Sensitivity analyses confirmed the robustness of the PSM.Conclusion: Patients receiving TP vs no-TP had higher median SAT. Of those with TP, those receiving PK-guided vs non-PK-guided TP experienced lower bleeding rates and higher SAT. PK-guided TP may help patients to be more active, potentially gaining the clinical and psychosocial benefits of exercise.Keywords: exercise, pharmacokinetic-guided treatment, prophylaxis, quality of life, treatment personalization, hemophilia Ahttps://www.dovepress.com/exploring-the-relationship-between-personalization-of-care-and-partici-peer-reviewed-fulltext-article-JBMExercisepharmacokinetic-guided treatmentprophylaxisquality of lifetreatment personalizationhemophilia A |
| spellingShingle | Blenkiron T Ferri Grazzi E Burke T Watt M Davis KH Exploring the Relationship Between Personalization of Care and Participation in Sport Activities Among People with Severe Hemophilia A Across Europe: Post Hoc Analysis of the CHESS II Study Journal of Blood Medicine Exercise pharmacokinetic-guided treatment prophylaxis quality of life treatment personalization hemophilia A |
| title | Exploring the Relationship Between Personalization of Care and Participation in Sport Activities Among People with Severe Hemophilia A Across Europe: Post Hoc Analysis of the CHESS II Study |
| title_full | Exploring the Relationship Between Personalization of Care and Participation in Sport Activities Among People with Severe Hemophilia A Across Europe: Post Hoc Analysis of the CHESS II Study |
| title_fullStr | Exploring the Relationship Between Personalization of Care and Participation in Sport Activities Among People with Severe Hemophilia A Across Europe: Post Hoc Analysis of the CHESS II Study |
| title_full_unstemmed | Exploring the Relationship Between Personalization of Care and Participation in Sport Activities Among People with Severe Hemophilia A Across Europe: Post Hoc Analysis of the CHESS II Study |
| title_short | Exploring the Relationship Between Personalization of Care and Participation in Sport Activities Among People with Severe Hemophilia A Across Europe: Post Hoc Analysis of the CHESS II Study |
| title_sort | exploring the relationship between personalization of care and participation in sport activities among people with severe hemophilia a across europe post hoc analysis of the chess ii study |
| topic | Exercise pharmacokinetic-guided treatment prophylaxis quality of life treatment personalization hemophilia A |
| url | https://www.dovepress.com/exploring-the-relationship-between-personalization-of-care-and-partici-peer-reviewed-fulltext-article-JBM |
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