Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies
Bordetella pertussis is the bacterial agent of whooping cough, an infectious disease that is reemerging despite high vaccine coverage. Newborn children are the most affected, not only because they are too young to be vaccinated but also due to qualitative and quantitative differences in their immune...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/7134168 |
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| author | Carolina Argondizo-Correia Ana Kelly Sousa Rodrigues Cyro Alves de Brito |
| author_facet | Carolina Argondizo-Correia Ana Kelly Sousa Rodrigues Cyro Alves de Brito |
| author_sort | Carolina Argondizo-Correia |
| collection | DOAJ |
| description | Bordetella pertussis is the bacterial agent of whooping cough, an infectious disease that is reemerging despite high vaccine coverage. Newborn children are the most affected, not only because they are too young to be vaccinated but also due to qualitative and quantitative differences in their immune system, which makes them more susceptible to infection and severe manifestations, leading to a higher mortality rate comparing to other groups. Until recently, prevention consisted of vaccinating children in the first year of life and the herd vaccination of people directly in touch with them, but the increase in cases demands more effective strategies that can overcome the developing immune response in early life and induce protection while children are most vulnerable. |
| format | Article |
| id | doaj-art-eae662c554c54f30bd9a02f5139ea1eb |
| institution | DOAJ |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-eae662c554c54f30bd9a02f5139ea1eb2025-08-20T03:21:10ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/71341687134168Neonatal Immunity to Bordetella pertussis Infection and Current Prevention StrategiesCarolina Argondizo-Correia0Ana Kelly Sousa Rodrigues1Cyro Alves de Brito2Institute of Tropical Medicine, University of São Paulo, Dr. Enéas de Carvalho Aguiar Avenue 470 Jardim América, São Paulo, SP 05403-000, BrazilImmunology Centre, Adolfo Lutz Institute, Dr. Arnaldo Avenue 351 Cerqueira César, São Paulo, SP 01246-000, BrazilInstitute of Tropical Medicine, University of São Paulo, Dr. Enéas de Carvalho Aguiar Avenue 470 Jardim América, São Paulo, SP 05403-000, BrazilBordetella pertussis is the bacterial agent of whooping cough, an infectious disease that is reemerging despite high vaccine coverage. Newborn children are the most affected, not only because they are too young to be vaccinated but also due to qualitative and quantitative differences in their immune system, which makes them more susceptible to infection and severe manifestations, leading to a higher mortality rate comparing to other groups. Until recently, prevention consisted of vaccinating children in the first year of life and the herd vaccination of people directly in touch with them, but the increase in cases demands more effective strategies that can overcome the developing immune response in early life and induce protection while children are most vulnerable.http://dx.doi.org/10.1155/2019/7134168 |
| spellingShingle | Carolina Argondizo-Correia Ana Kelly Sousa Rodrigues Cyro Alves de Brito Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies Journal of Immunology Research |
| title | Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies |
| title_full | Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies |
| title_fullStr | Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies |
| title_full_unstemmed | Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies |
| title_short | Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies |
| title_sort | neonatal immunity to bordetella pertussis infection and current prevention strategies |
| url | http://dx.doi.org/10.1155/2019/7134168 |
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