Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes Mellitus
Objective. The alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio is thought to be related to metabolic disorders and insulin resistance. Type 2 diabetes mellitus (T2DM) is a high-risk population for low muscle mass. This study was performed to evaluate the association between ALT/A...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/9480228 |
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| author | Wenjie Ma Wenchao Hu Yuantao Liu Lanjie He |
| author_facet | Wenjie Ma Wenchao Hu Yuantao Liu Lanjie He |
| author_sort | Wenjie Ma |
| collection | DOAJ |
| description | Objective. The alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio is thought to be related to metabolic disorders and insulin resistance. Type 2 diabetes mellitus (T2DM) is a high-risk population for low muscle mass. This study was performed to evaluate the association between ALT/AST and muscle mass in subjects with T2DM. Method. This cross-sectional study enrolled 1068 subjects (566 males and 502 females) with T2DM. General information, medical history, and blood samples were collected. Skeletal muscle index (SMI) was detected using dual-energy X-ray absorptiometry. Logistic regression analysis was utilized to determine the correlation of ALT/AST and low muscle mass in subjects with T2DM. Multiple linear regression analysis was utilized to evaluate the association between ALT/AST, SMI and other metabolic characteristics. Result. Of all subjects, 115 men (20.3%) and 71 women (14.1%) presented low muscle mass. ALT/AST was related to an increased risk for low muscle mass in both genders. Multiple linear regression analysis displayed that SMI was negatively associated with ALT/AST, age, glycosylated hemoglobin (HbA1c), and high-density lipoprotein cholesterol (HDL) in male group. While in female group, SMI was positively associated with systolic blood pressure (SBP) and negatively associated with ALT/AST and age. Furthermore, ALT/AST was associated with age and BMI in both genders. Conclusion. ALT/AST was negatively associated with muscle mass in subjects with T2DM. |
| format | Article |
| id | doaj-art-eadbc5db52a24827990a8163ae4e3f08 |
| institution | OA Journals |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-eadbc5db52a24827990a8163ae4e3f082025-08-20T02:21:39ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/9480228Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes MellitusWenjie Ma0Wenchao Hu1Yuantao Liu2Lanjie He3Department of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyObjective. The alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio is thought to be related to metabolic disorders and insulin resistance. Type 2 diabetes mellitus (T2DM) is a high-risk population for low muscle mass. This study was performed to evaluate the association between ALT/AST and muscle mass in subjects with T2DM. Method. This cross-sectional study enrolled 1068 subjects (566 males and 502 females) with T2DM. General information, medical history, and blood samples were collected. Skeletal muscle index (SMI) was detected using dual-energy X-ray absorptiometry. Logistic regression analysis was utilized to determine the correlation of ALT/AST and low muscle mass in subjects with T2DM. Multiple linear regression analysis was utilized to evaluate the association between ALT/AST, SMI and other metabolic characteristics. Result. Of all subjects, 115 men (20.3%) and 71 women (14.1%) presented low muscle mass. ALT/AST was related to an increased risk for low muscle mass in both genders. Multiple linear regression analysis displayed that SMI was negatively associated with ALT/AST, age, glycosylated hemoglobin (HbA1c), and high-density lipoprotein cholesterol (HDL) in male group. While in female group, SMI was positively associated with systolic blood pressure (SBP) and negatively associated with ALT/AST and age. Furthermore, ALT/AST was associated with age and BMI in both genders. Conclusion. ALT/AST was negatively associated with muscle mass in subjects with T2DM.http://dx.doi.org/10.1155/2022/9480228 |
| spellingShingle | Wenjie Ma Wenchao Hu Yuantao Liu Lanjie He Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes Mellitus Mediators of Inflammation |
| title | Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes Mellitus |
| title_full | Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes Mellitus |
| title_short | Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes Mellitus |
| title_sort | association between alt ast and muscle mass in patients with type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2022/9480228 |
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