KLF4: a multifunctional nexus connecting tumor progression and immune regulation
Krüppel-like factors (KLFs) regulate various biological processes such as cell proliferation, migration, invasion, and differentiation as gene transcription factors. Signaling pathways which mediated by KLF4 and KLF4 have a sophisticated role in tumors due to multiple factors, including the types or...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1514780/full |
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| author | Yunjie Ju Wen Xiao Bryan James Mathis Ying Shi |
| author_facet | Yunjie Ju Wen Xiao Bryan James Mathis Ying Shi |
| author_sort | Yunjie Ju |
| collection | DOAJ |
| description | Krüppel-like factors (KLFs) regulate various biological processes such as cell proliferation, migration, invasion, and differentiation as gene transcription factors. Signaling pathways which mediated by KLF4 and KLF4 have a sophisticated role in tumors due to multiple factors, including the types or stage of tumors. KLF4 plays a promoter role in tumorigenesis and development, or tumor suppressor as a context-dependent anti- and pro-inflammatory factor. KLF4 over-expression increases CD8+T cell differentiation and enhances the antitumor immunity. This review aims to provide information about the relationship of KLF4 in immunity with tumors and to guide the future study. |
| format | Article |
| id | doaj-art-ead9185eab8b4b3b8d5c2e90c8446c49 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ead9185eab8b4b3b8d5c2e90c8446c492025-02-10T11:38:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15147801514780KLF4: a multifunctional nexus connecting tumor progression and immune regulationYunjie Ju0Wen Xiao1Bryan James Mathis2Ying Shi3Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaClinical Research Manuscript Elevation Service, University of Tsukuba Institute of Medicine, Tsukuba, JapanDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKrüppel-like factors (KLFs) regulate various biological processes such as cell proliferation, migration, invasion, and differentiation as gene transcription factors. Signaling pathways which mediated by KLF4 and KLF4 have a sophisticated role in tumors due to multiple factors, including the types or stage of tumors. KLF4 plays a promoter role in tumorigenesis and development, or tumor suppressor as a context-dependent anti- and pro-inflammatory factor. KLF4 over-expression increases CD8+T cell differentiation and enhances the antitumor immunity. This review aims to provide information about the relationship of KLF4 in immunity with tumors and to guide the future study.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1514780/fullKLF4tumor microenvironment (TME)immune regulationoncogenesistumor immunology |
| spellingShingle | Yunjie Ju Wen Xiao Bryan James Mathis Ying Shi KLF4: a multifunctional nexus connecting tumor progression and immune regulation Frontiers in Immunology KLF4 tumor microenvironment (TME) immune regulation oncogenesis tumor immunology |
| title | KLF4: a multifunctional nexus connecting tumor progression and immune regulation |
| title_full | KLF4: a multifunctional nexus connecting tumor progression and immune regulation |
| title_fullStr | KLF4: a multifunctional nexus connecting tumor progression and immune regulation |
| title_full_unstemmed | KLF4: a multifunctional nexus connecting tumor progression and immune regulation |
| title_short | KLF4: a multifunctional nexus connecting tumor progression and immune regulation |
| title_sort | klf4 a multifunctional nexus connecting tumor progression and immune regulation |
| topic | KLF4 tumor microenvironment (TME) immune regulation oncogenesis tumor immunology |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1514780/full |
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