Association between allergic diseases and mucosal healing in ulcerative colitis
Abstract Allergic diseases and ulcerative colitis (UC) share pathophysiological similarities. This study aimed to investigate the unclear association between allergic diseases and mucosal healing (MH), an important factor in the prognosis of UC. We studied 289 Japanese patients with UC. Information...
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| Language: | English |
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85916-0 |
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| author | Yasunori Yamamoto Shinya Furukawa Osamu Yoshida Teruki Miyake Kana Shiraishi Yu Hashimoto Kazuhiro Tange Shogo Kitahata Tomoyuki Ninomiya Sen Yagi Hanayama Masakazu Seiyuu Suzuki Naozumi Shibata Hidehiro Murakami Katsuhisa Ohashi Hideomi Tomida Eiji Takeshita Yoshio Ikeda Yoichi Hiasa |
| author_facet | Yasunori Yamamoto Shinya Furukawa Osamu Yoshida Teruki Miyake Kana Shiraishi Yu Hashimoto Kazuhiro Tange Shogo Kitahata Tomoyuki Ninomiya Sen Yagi Hanayama Masakazu Seiyuu Suzuki Naozumi Shibata Hidehiro Murakami Katsuhisa Ohashi Hideomi Tomida Eiji Takeshita Yoshio Ikeda Yoichi Hiasa |
| author_sort | Yasunori Yamamoto |
| collection | DOAJ |
| description | Abstract Allergic diseases and ulcerative colitis (UC) share pathophysiological similarities. This study aimed to investigate the unclear association between allergic diseases and mucosal healing (MH), an important factor in the prognosis of UC. We studied 289 Japanese patients with UC. Information on allergic diseases (bronchial asthma, atopic dermatitis, pollen allergy, food allergy, and drug allergy), as diagnosed by physicians, was collected through self-reported questionnaires. The definition of MH was Mayo Endoscopic Score 0. The association between each allergic disease and its multimorbidity with MH was evaluated using multivariate logistic regression analyses. Pollen allergy was the most common allergic condition (36.3%). Pollen allergy and food allergy were independently associated with MH (pollen allergy adjusted OR: 1.82 [95% CI: 1.01–3.26]; food allergy adjusted OR: 3.47 [95% CI: 1.26–9.68]). The rates of MH for 0 and 3 or more allergic diseases were 24.6% and 4.2%, respectively. After adjustment for confounders, 3 or more allergic diseases were independently associated with MH (adjusted OR: 8.13 [95% CI: 2.17–34.04], p for trend = 0.020). This study demonstrates a significant positive association between specific allergic diseases (pollen and food allergies) and MH in UC patients, with a stronger association in cases of allergic multimorbidity. |
| format | Article |
| id | doaj-art-ead58331b31e478d870dc69c186152e0 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ead58331b31e478d870dc69c186152e02025-01-12T12:15:42ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-025-85916-0Association between allergic diseases and mucosal healing in ulcerative colitisYasunori Yamamoto0Shinya Furukawa1Osamu Yoshida2Teruki Miyake3Kana Shiraishi4Yu Hashimoto5Kazuhiro Tange6Shogo Kitahata7Tomoyuki Ninomiya8Sen Yagi9Hanayama Masakazu10Seiyuu Suzuki11Naozumi Shibata12Hidehiro Murakami13Katsuhisa Ohashi14Hideomi Tomida15Eiji Takeshita16Yoshio Ikeda17Yoichi Hiasa18Endoscopy Center, Ehime University HospitalHealth Services Center, Ehime UniversityDepartment of Gastroenterology and Metabology, Ehime University Graduate School of MedicineDepartment of Gastroenterology and Metabology, Ehime University Graduate School of MedicineDepartment of Gastroenterology and Metabology, Ehime University Graduate School of MedicineDepartment of Gastroenterology and Metabology, Ehime University Graduate School of MedicineDepartment of Inflammatory Bowel Diseases and Therapeutics, Ehime University Graduate School of MedicineDepartment of Gastroenterology, Ehime Prefectural Central HospitalDepartment of Gastroenterology, Ehime Prefectural Central HospitalDepartment of Internal Medicine, Saiseikai Imabari HospitalDepartment of Gastroenterology, Matsuyama Shimin HospitalDepartment of Gastroenterology, Sumitomo Besshi HospitalDepartment of Gastroenterology, Ehime Prefectural Niihama HospitalDepartment of Internal Medicine, Saiseikai Matsuyama HospitalOHASHI Clinic Participate in Gastro-Enterology and Ano-ProctologyEndoscopy Center, Ehime University HospitalDepartment of Inflammatory Bowel Diseases and Therapeutics, Ehime University Graduate School of MedicineEndoscopy Center, Ehime University HospitalDepartment of Gastroenterology and Metabology, Ehime University Graduate School of MedicineAbstract Allergic diseases and ulcerative colitis (UC) share pathophysiological similarities. This study aimed to investigate the unclear association between allergic diseases and mucosal healing (MH), an important factor in the prognosis of UC. We studied 289 Japanese patients with UC. Information on allergic diseases (bronchial asthma, atopic dermatitis, pollen allergy, food allergy, and drug allergy), as diagnosed by physicians, was collected through self-reported questionnaires. The definition of MH was Mayo Endoscopic Score 0. The association between each allergic disease and its multimorbidity with MH was evaluated using multivariate logistic regression analyses. Pollen allergy was the most common allergic condition (36.3%). Pollen allergy and food allergy were independently associated with MH (pollen allergy adjusted OR: 1.82 [95% CI: 1.01–3.26]; food allergy adjusted OR: 3.47 [95% CI: 1.26–9.68]). The rates of MH for 0 and 3 or more allergic diseases were 24.6% and 4.2%, respectively. After adjustment for confounders, 3 or more allergic diseases were independently associated with MH (adjusted OR: 8.13 [95% CI: 2.17–34.04], p for trend = 0.020). This study demonstrates a significant positive association between specific allergic diseases (pollen and food allergies) and MH in UC patients, with a stronger association in cases of allergic multimorbidity.https://doi.org/10.1038/s41598-025-85916-0Allergic diseasesUlcerative colitisInflammatory bowel diseaseAtopic dermatitisFood allergy |
| spellingShingle | Yasunori Yamamoto Shinya Furukawa Osamu Yoshida Teruki Miyake Kana Shiraishi Yu Hashimoto Kazuhiro Tange Shogo Kitahata Tomoyuki Ninomiya Sen Yagi Hanayama Masakazu Seiyuu Suzuki Naozumi Shibata Hidehiro Murakami Katsuhisa Ohashi Hideomi Tomida Eiji Takeshita Yoshio Ikeda Yoichi Hiasa Association between allergic diseases and mucosal healing in ulcerative colitis Scientific Reports Allergic diseases Ulcerative colitis Inflammatory bowel disease Atopic dermatitis Food allergy |
| title | Association between allergic diseases and mucosal healing in ulcerative colitis |
| title_full | Association between allergic diseases and mucosal healing in ulcerative colitis |
| title_fullStr | Association between allergic diseases and mucosal healing in ulcerative colitis |
| title_full_unstemmed | Association between allergic diseases and mucosal healing in ulcerative colitis |
| title_short | Association between allergic diseases and mucosal healing in ulcerative colitis |
| title_sort | association between allergic diseases and mucosal healing in ulcerative colitis |
| topic | Allergic diseases Ulcerative colitis Inflammatory bowel disease Atopic dermatitis Food allergy |
| url | https://doi.org/10.1038/s41598-025-85916-0 |
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