Conventional type 1 dendritic cells in the lymph nodes aggravate neuroinflammation after spinal cord injury by promoting CD8+ T cell expansion

Conventional type 1 dendritic cells in the lymph nodes aggravate neuroinflammation after spinal cord injury by promoting CD8+ T cell expansion

Abstract Background Adaptive immune response is at the core of the mechanism of secondary spinal cord injury (SCI). This study aims to explore the molecular mechanism by which classical dendritic cells (cDC1s) influence CD8+ T cell expansion in SCI. Methods Peripheral blood samples from patients wit...

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Bibliographic Details
Main Authors: Li-Qing Wang, Xiao-Yi Wang, Yue-Hui Ma, Heng-Jun Zhou
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Medicine
Subjects:
Spinal cord injury
Neuroinflammation
Conventional type 1 dendritic cells
Lymph nodes
CD8+ T cell
Online Access:https://doi.org/10.1186/s10020-024-01059-4
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