Loss of MNX1 Sensitizes Tumors to Cytotoxic T Cells by Degradation of PD‐L1 mRNA

Loss of MNX1 Sensitizes Tumors to Cytotoxic T Cells by Degradation of PD‐L1 mRNA

Abstract Immune checkpoint blockade (ICB) therapy, targeting programmed cell death ligand‐1 (PD‐L1)/programmed cell death protein 1 (PD‐1) axis and cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4), has exhibited amazing clinical outcomes in various types of cancers. However, only a small portion...

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Main Authors: Zhengzheng Li, Lei Chen, Ge Zhang, Shuang Wang, Enhang Xu, Jinglei Teng, Jiancheng Xu, Fang Peng, Qingjie Min, Zhuoya Wang, Shujuan Shao, Lianmei Zhao, Baoen Shan, Yang Wang, Qimin Zhan, Xuefeng Liu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
immunotherapy
MNX1
MNX1‐AS1
PD‐L1
tumor immune escape
Online Access:https://doi.org/10.1002/advs.202403077
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