Synthesis and Insecticidal/Fungicidal Activities of Triazone Derivatives Containing Acylhydrazone Moieties
A series of novel triazone derivatives containing aldehyde hydrazone or ketone hydrazone moieties were designed, synthesized and their biological activities were investigated against <i>Aphis craccivora</i>, <i>Culex pipiens pallens</i>, <i>Helicoverpa armigera</i>...
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2025-01-01
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| author | Peipei Cui Yan Yang |
| author_facet | Peipei Cui Yan Yang |
| author_sort | Peipei Cui |
| collection | DOAJ |
| description | A series of novel triazone derivatives containing aldehyde hydrazone or ketone hydrazone moieties were designed, synthesized and their biological activities were investigated against <i>Aphis craccivora</i>, <i>Culex pipiens pallens</i>, <i>Helicoverpa armigera</i>, <i>Ostrinia nubilalis</i>, <i>Mythimna separata</i> and 14 Kinds of fungi. Most of the aldehyde hydrazone exhibited excellent insecticidal activities against <i>A. craccivora</i>. In particular, the aphicidal activities of compounds <b>3t</b> (35%) and <b>3w</b> (30%) were equivalent to pymetrozine (30%) at 5 mg/kg. The aphicidal activities of derivatives <b>3p</b>, <b>3u</b>, <b>3y</b>, <b>5g</b>, <b>5i</b>, <b>5l</b>, <b>5q</b> and <b>5u</b> against <i>C. pipiens pallens</i> were higher than that of pymetrozine. Compound <b>3u</b> (100%) exhibited good larvicidal activities against <i>C. pipiens pallens</i> at 0.25 mg/kg. Most derivatives exhibited broad-spectrum fungicidal activities against 14 kinds of plant fungi at 50 mg/kg. Thirty-nine compounds exhibited a more than 50% inhibition rate against <i>Physalospora piricola</i>. Compounds <b>3h</b>, <b>3t</b> and <b>3w</b> were expected to be the leading structure for the development of new triazone insecticides agents. |
| format | Article |
| id | doaj-art-ead1450a74dd4ee5a8f4546399ba36b2 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Molecules |
| spelling | doaj-art-ead1450a74dd4ee5a8f4546399ba36b22025-01-24T13:43:41ZengMDPI AGMolecules1420-30492025-01-0130234010.3390/molecules30020340Synthesis and Insecticidal/Fungicidal Activities of Triazone Derivatives Containing Acylhydrazone MoietiesPeipei Cui0Yan Yang1College of Architecture and Arts, Taiyuan University of Technology, Jinzhong 030060, ChinaCollege of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, ChinaA series of novel triazone derivatives containing aldehyde hydrazone or ketone hydrazone moieties were designed, synthesized and their biological activities were investigated against <i>Aphis craccivora</i>, <i>Culex pipiens pallens</i>, <i>Helicoverpa armigera</i>, <i>Ostrinia nubilalis</i>, <i>Mythimna separata</i> and 14 Kinds of fungi. Most of the aldehyde hydrazone exhibited excellent insecticidal activities against <i>A. craccivora</i>. In particular, the aphicidal activities of compounds <b>3t</b> (35%) and <b>3w</b> (30%) were equivalent to pymetrozine (30%) at 5 mg/kg. The aphicidal activities of derivatives <b>3p</b>, <b>3u</b>, <b>3y</b>, <b>5g</b>, <b>5i</b>, <b>5l</b>, <b>5q</b> and <b>5u</b> against <i>C. pipiens pallens</i> were higher than that of pymetrozine. Compound <b>3u</b> (100%) exhibited good larvicidal activities against <i>C. pipiens pallens</i> at 0.25 mg/kg. Most derivatives exhibited broad-spectrum fungicidal activities against 14 kinds of plant fungi at 50 mg/kg. Thirty-nine compounds exhibited a more than 50% inhibition rate against <i>Physalospora piricola</i>. Compounds <b>3h</b>, <b>3t</b> and <b>3w</b> were expected to be the leading structure for the development of new triazone insecticides agents.https://www.mdpi.com/1420-3049/30/2/340triazonehydrazonebiological activities |
| spellingShingle | Peipei Cui Yan Yang Synthesis and Insecticidal/Fungicidal Activities of Triazone Derivatives Containing Acylhydrazone Moieties Molecules triazone hydrazone biological activities |
| title | Synthesis and Insecticidal/Fungicidal Activities of Triazone Derivatives Containing Acylhydrazone Moieties |
| title_full | Synthesis and Insecticidal/Fungicidal Activities of Triazone Derivatives Containing Acylhydrazone Moieties |
| title_fullStr | Synthesis and Insecticidal/Fungicidal Activities of Triazone Derivatives Containing Acylhydrazone Moieties |
| title_full_unstemmed | Synthesis and Insecticidal/Fungicidal Activities of Triazone Derivatives Containing Acylhydrazone Moieties |
| title_short | Synthesis and Insecticidal/Fungicidal Activities of Triazone Derivatives Containing Acylhydrazone Moieties |
| title_sort | synthesis and insecticidal fungicidal activities of triazone derivatives containing acylhydrazone moieties |
| topic | triazone hydrazone biological activities |
| url | https://www.mdpi.com/1420-3049/30/2/340 |
| work_keys_str_mv | AT peipeicui synthesisandinsecticidalfungicidalactivitiesoftriazonederivativescontainingacylhydrazonemoieties AT yanyang synthesisandinsecticidalfungicidalactivitiesoftriazonederivativescontainingacylhydrazonemoieties |