Plasmodium falciparum Rab5B is an N-terminally myristoylated Rab GTPase that is targeted to the parasite's plasma and food vacuole membranes.

Plasmodium falciparum Rab5B is an N-terminally myristoylated Rab GTPase that is targeted to the parasite's plasma and food vacuole membranes.

Plasmodium falciparum (Pf) has a family of 11 Rab GTPases to regulate its vesicular transport. However, PfRab5B is unique in lacking a C-terminal geranyl-geranylation motif, while having N-terminal palmitoylation and myristoylation motifs. We show that the N-terminal glycine is required for PfRab5B...

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Main Authors: Carinne Ndjembo Ezougou, Fathia Ben-Rached, David K Moss, Jing-Wen Lin, Sally Black, Ellen Knuepfer, Judith L Green, Shahid M Khan, Amitabha Mukhopadhyay, Chris J Janse, Isabelle Coppens, Hélène Yera, Anthony A Holder, Gordon Langsley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0087695
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