Bioinformatics analysis combined with experimental validation reveals the novel mechanisms of multi-targets of dapagliflozin attenuating diabetic liver injury

Bioinformatics analysis combined with experimental validation reveals the novel mechanisms of multi-targets of dapagliflozin attenuating diabetic liver injury

ObjectiveDiabetic liver injury, a chronic complication of diabetes mellitus (DM), has been extensively documented. Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has shown significant therapeutic benefits in clinical trials for the management of diabetes However, the specific me...

Full description

Saved in:

Bibliographic Details
Main Authors:	Pengyu Wang, Zhen Sun, Qing Lan, Shuo Zhang, Yan Song, Leiming Yang, Mi Chen, Jianfen Shen, Qi Huang, Youzhi Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Endocrinology
Subjects:	dapagliflozin diabetic liver injury ERK/IKKβ/NF-κB pathways bioinformatics data mining metabolic disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1519153/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Double trouble: cytosolic and nuclear IKKα in cancer
by: Kirsty Tinto, et al.
Published: (2025-08-01)

Investigating the role of hyperexpressed HCN1 in inducing myocardial infarction through activation of the NF-κB signaling pathway
by: Liang Xiao, et al.
Published: (2024-12-01)

Identification of lipid metabolism-related genes in dapagliflozin treated rats with diabetic cardiomyopathy by bioinformatics
by: Xun Huang, et al.
Published: (2025-03-01)

The Role of IKK-2/NF-κB Signaling Cascade in the Activation of Peritoneal Macrophages by Humic Acids of Peat
by: E. S. Trofimova, et al.
Published: (2022-09-01)

Synthesis and Anti-Liver Fibrosis Research of Aspartic Acid Derivatives
by: Miao Lv, et al.
Published: (2024-10-01)

The effect of Euonymus Fortunei extract combined with oxaliplatin on the IKKβ/NF-κB signaling pathway in colon cancer
by: Liu Jiaxuan, et al.
Published: (2024-10-01)

Investigating Natural Product Inhibitors of IKKα: Insights from Integrative In Silico and Experimental Validation
by: Muhammad Yasir, et al.
Published: (2025-05-01)

Melatonin Reduces Inflammation in the Lung Tissue of Type 1 Diabetic Mice Through the ERK/NF-κB Signaling Pathway
by: Jafar Rezaie, et al.
Published: (2025-06-01)

The Potential Effect of Dapagliflozin and Liraglutide in Attenuating Cardio-Renal Injuries in Diabetic Rats
by: Albanna AA, et al.
Published: (2025-07-01)

Impairment of neuronal tyrosine phosphatase STEP worsens post-ischemic inflammation and brain injury under hypertensive condition
by: Prabu Paramasivam, et al.
Published: (2024-10-01)

Exploring the effect of dapagliflozin on coronary inflammation in type 2 diabetes patients based on the coronary artery perivascular fat attenuation index
by: Xuehua Liu, et al.
Published: (2025-04-01)

Dapagliflozin effect on functional mitral regurgitation and myocardial remodelling: The DEFORM trial
by: Zhuoshan Huang, et al.
Published: (2025-08-01)

Linalool and linalyl acetate attenuated canonical pathway of NF-κB signaling in HepG2 cells
by: Cheng-Hao Wu, et al.
Published: (2025-12-01)

Dapagliflozin ameliorates intestinal stem cell aging by regulating the MAPK signaling pathway in Drosophila
by: Jinhua Yan, et al.
Published: (2025-04-01)

Effects of dapagliflozin on podocyte damage and oxidative stress in patients with diabetic nephropathy
by: Yajing Shi, et al.
Published: (2025-08-01)

Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis
by: Yuejiao Lan, et al.
Published: (2025-07-01)

DRESS syndrome with the use of dapagliflozin: A case report and review of literature
by: Rebecca Badawi, et al.
Published: (2025-07-01)

The beneficial effects of dapagliflozin on the course of experimental urate nephrolithiasis
by: V. Yu. Perfil’ev, et al.
Published: (2017-04-01)

Investigating the Effect and Potential Mechanism of Rhamnetin 3-<i>O</i>-α-Rhamnoside on Acute Liver Injury In Vivo and In Vitro
by: Dandan Deng, et al.
Published: (2025-01-01)

The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα
by: Tao Wang, et al.
Published: (2024-12-01)

Integrated network pharmacology reveals the mechanism of action of Xianlinggubao prescription for inflammation in osteoarthritis
by: Jingyi Hou, et al.
Published: (2025-05-01)

The The Impact of Dapagliflozin on Aldosterone Hormone in Rats with Heart Failure
by: Skala Mamand Jawhar, et al.
Published: (2023-09-01)

Repurposing dapagliflozin for Alzheimer's disease: a mechanistic exploration
by: Marwa M. Saeed
Published: (2024-12-01)

Cadmium induced ferroptosis and inflammation in sheep via targeting ACSL4/NF-κB axis
by: Zimeng Ma, et al.
Published: (2025-08-01)

Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production
by: Yan Tian, et al.
Published: (2025-12-01)

RNA polymerase II subunit 5-mediating protein limits TLR4-induced innate immune activation in macrophages by inhibiting IKKβ/NF-κB signaling during sepsis
by: Shu-jie Pang, et al.
Published: (2025-06-01)

Cost-effectiveness of dapagliflozin for the treatment of heart failure: a systematic review
by: Zehui Jiang, et al.
Published: (2025-05-01)

Cost-utility analysis of empagliflozin compared with dapagliflozin in patients with type 2 diabetes in China
by: Huiyuan Zhang, et al.
Published: (2025-07-01)

Combination of dapagliflozin and pioglitazone lacks superiority against monotherapy in streptozotocin-induced nephropathy
by: Aneta Cinakova, et al.
Published: (2025-01-01)

Dapagliflozin inhibits ferroptosis and ameliorates renal fibrosis in diabetic C57BL/6J mice
by: Zhen Zhang, et al.
Published: (2025-02-01)

Celastrol attenuates sodium oxalate-induced acute kidney injury and crystal deposition by inhibiting NF-κB
by: LIU Yiheng, et al.
Published: (2025-04-01)

Regulation of pyroptosis by NF-κB signaling
by: Ling Yang, et al.
Published: (2025-01-01)

The Effect of Dapagliflozin, a Sodium–Glucose Co-Transporter 2 Inhibitor, on Vancomycin-Induced Nephrotoxicity in Rats
by: Seyhmus Tan, et al.
Published: (2025-06-01)

Porcine Teschovirus 2 3C<sup>pro</sup> Evades Host Antiviral Innate Immunity by Inhibiting the IFN-β Signaling Pathway
by: Xin-Yu Zhang, et al.
Published: (2025-05-01)

Pretreatment GFR Slopes Predict Dapagliflozin Response in IgA Nephropathy
by: Hiroyuki Ueda, et al.
Published: (2025-07-01)

Effect of dapagliflozin on myocardial function changes in early spontaneously hypertensive rats: a study based on longitudinal layer-specific strain
by: CHEN Xuemei, et al.
Published: (2025-03-01)

Impact of dapagliflozin administration on remodeling marker and clinical outcomes of stemi patients with diabetes mellitus: a controlled clinical trial
by: Abdullah Heshmat, et al.
Published: (2025-08-01)

Cedrol attenuates acute ischemic injury through inhibition of microglia-associated neuroinflammation via ERβ-NF-κB signaling pathways
by: Yu Bi, et al.
Published: (2024-11-01)

Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target IκBα and activate NF-κB signaling
by: Huiyu Luo, et al.
Published: (2025-05-01)

Optimization and validation of UPLC method for dapagliflozin and candesartan cilexetil in an on-demand formulation: Analytical quality by design approach
by: Elzayat Ehab M., et al.
Published: (2025-07-01)