The crystal structure of the toxin EspC from enteropathogenic Escherichia coli reveals the mechanism that governs host cell entry and cytotoxicity

The crystal structure of the toxin EspC from enteropathogenic Escherichia coli reveals the mechanism that governs host cell entry and cytotoxicity

Enteropathogenic E. coli (EPEC) is a significant cause of diarrhea, leading to high infant mortality rates. A key toxin produced by EPEC is the EspC autotransporter, which is regulated alongside genes from the locus of enterocyte effacement (LEE), which collectively result in the characteristic atta...

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Bibliographic Details
Main Authors: Akila U. Pilapitiya, Lilian Hor, Jing Pan, Lakshmi C. Wijeyewickrema, Robert N. Pike, Denisse L. Leyton, Jason J Paxman, Begoña Heras
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Enteropathogenic E. coli
autotransporter protein
serine protease
toxins
bacterial infections
secretion system
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2483777
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