Investigating the shared genetic architecture between Parkinson's disease and magnetic susceptibility of the substantia nigra

Investigating the shared genetic architecture between Parkinson's disease and magnetic susceptibility of the substantia nigra

Parkinson's disease (PD) is a common and progressively deteriorating neurodegenerative disorder thatprofoundly affects millions of individuals worldwide. Neuroimaging research has consistently demonstrated abnormalities in quantitative susceptibility mapping (QSM) within the substantia nigra (S...

Full description

Saved in:

Bibliographic Details
Main Author:	Jilian Fu
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2025-09-01
Series:	Meta-Radiology
Subjects:	Parkinson's disease Quantitative susceptibility mapping (QSM) Substantia nigra Genetic pleiotropy Drug-gene interactions
Online Access:	http://www.sciencedirect.com/science/article/pii/S2950162825000256
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses
by: Hui-Hui Fan, et al.
Published: (2025-04-01)

Structural Connectivity of the Substantia Nigra: A Comprehensive Review of Diffusion Imaging and Tractography Studies
by: Iva Bublíková, et al.
Published: (2025-07-01)

Neuroprotective Effects of Bacterial Melanin in a Rotenone-Induced Parkinson’s Disease Rat Model: Electrophysiological Evidence from Cortical Stimulation of Substantia Nigra Neurons
by: John Sarkissian, et al.
Published: (2025-05-01)

Transcranial sonography in Parkinson’s disease
by: I. V. Bayborodina, et al.
Published: (2018-03-01)

Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta
by: William S. Conrad, et al.
Published: (2024-12-01)

Transcranial parenhymal sonography in the diagnosis of Parkinson's disease
by: Mijajlović Milija, et al.
Published: (2008-01-01)

Dorsal hyperintensity and iron deposition patterns in the substantia nigra of Parkinson’s disease, idiopathic REM sleep behavior disorder, and Parkinson-plus syndromes at 7T MRI: a prospective diagnostic study
by: Dongning Su, et al.
Published: (2025-07-01)

Gluten and its relationship with inflammation and Parkinson's Disease: A literature review
by: Zohaer Muttalib, et al.
Published: (2025-03-01)

Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease
by: Weimin Qi, et al.
Published: (2025-06-01)

Metabolic Dysfunction in Parkinson’s Disease: Unraveling the Glucose–Lipid Connection
by: Jeswinder Sian-Hulsmann, et al.
Published: (2024-12-01)

Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia
by: Zhe Lu, et al.
Published: (2025-08-01)

Harnessing routine MRI for the early screening of Parkinson’s disease: a multicenter machine learning study using T2-weighted FLAIR imaging
by: Junyan Fu, et al.
Published: (2025-04-01)

Oligodendrocyte-Specific STAT5B Overexpression Ameliorates Myelin Impairment in Experimental Models of Parkinson’s Disease
by: Yibo Li, et al.
Published: (2025-07-01)

Relaxometry network based on MRI R2⁎ mapping revealing brain iron accumulation patterns in Parkinson's disease
by: Weizhao Lu, et al.
Published: (2024-12-01)

THE ROLE OF HIGH FIELD MAGNETIC RESONANCE IMAGING OF THE BRAIN IN THE DIAGNOSIS OF EARLY-STAGE PARKINSON’S DISEASE: A CLINICAL CASE
by: N. A. Shnayder, et al.
Published: (2017-07-01)

Assessment of neurotoxicity of rotenone and the possible protective effect of alpha lipoic acid in adult male albino rats
by: Miriam Ramzy Riad, et al.
Published: (2025-12-01)

Study on multi-parametric texture analysis for quantifying brain magnetic susceptibility in patients with Parkinson′s disease
by: ZHAO Xinxin, et al.
Published: (2025-01-01)

The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity
by: Daniel Torrente, et al.
Published: (2025-01-01)

Konstantin N. Tretiakoff in Brazil a historical perspective and discussion of his contribution to brazilian neuroscience Konstantin N. Tretiakoff no Brasil: uma perspectiva histórica e discussão de sua contribuição à neurociência brasileira
by: Luiz Augusto F. Andrade, et al.
Published: (2009-06-01)

Abnormal EEG Effects of Acute Apomorphine Injection in 5xFAD Transgenic Mice Are Partially Normalized in Those Chronically Pretreated with Apomorphine: The Time–Frequency Clustering of EEG Spectra
by: Vasily Vorobyov, et al.
Published: (2024-10-01)

Sex Hormones and Prognosis of Neonatal Seizures
by: J Gordon Millichap
Published: (2004-12-01)

The mechanism of electroacupuncture-mediated improvement in Parkinson’s disease by inhibiting ferroptosis through activating the Nrf2/GPX4 signal pathway
by: Min Wang, et al.
Published: (2025-05-01)

The subspecific characters and distribution of the New World Skimmers - Rynchops nigra The subspecific characters and distribution of the New World Skimmers - Rynchops nigra
by: Wetmore Alexander
Published: (1944-09-01)

Thalamic iron in multiple sclerosis: Waning support for the early-rise late-decline hypothesis
by: Fahad Salman, et al.
Published: (2025-01-01)

Dopamine function in adolescent social anxiety: Insights from neuromelanin-sensitive MRI
by: Margherita L. Calderaro, et al.
Published: (2025-09-01)

Association between deep gray matter iron deposition and clinical symptoms in Parkinson’s disease: a quantitative susceptibility mapping study
by: Hui Zhao, et al.
Published: (2025-01-01)

Neurotransmitter imbalance, glutathione depletion and concomitant susceptibility increase in Parkinson’s disease
by: Su Yan, et al.
Published: (2025-01-01)

Robust computation of subcortical functional connectivity guided by quantitative susceptibility mapping: An application in Parkinson’s disease diagnosis
by: Jianmei Qin, et al.
Published: (2025-07-01)

The effect of cannabinoid type Ⅱ receptor on the excitability of substantia nigra dopaminergic neurons
by: Sha Zhao, et al.
Published: (2025-02-01)

Adeno-associated viral vectors for modeling Parkinson’s disease in non-human primates
by: Julia Chocarro, et al.
Published: (2026-01-01)

Localization and connections of the tail of caudate and caudal putamen in mouse brain
by: Run-Zhe Ma, et al.
Published: (2025-08-01)

A pilot study assessing the clinical utility of deep learning-reconstructed 3D-echo-planar-imaging-based quantitative susceptibility mapping in multiple sclerosis
by: Dimitrios G. Gkotsoulias, et al.
Published: (2025-07-01)

Structural and iron content changes in subcortical vascular mild cognitive impairment: a combined voxel-based morphometry and quantitative susceptibility mapping study
by: Yushuang Liu, et al.
Published: (2025-01-01)

A case of tinea nigra in children
by: Tengteng Xin, et al.
Published: (2025-06-01)

Depression is marked by differences in structural covariance between deep-brain nuclei and sensorimotor cortex
by: Siraj Lyons, et al.
Published: (2025-04-01)

Echogenicity of the substantia nigra region in Parkinson's disease
by: Edson Bor-Seng-Shu, et al.
Published: (2012-02-01)

Effect of moderate hyperbilirubinemia on an infant’s brain: a quantitative susceptibility mapping and 1H-MRS study
by: Ru Zhao, et al.
Published: (2025-03-01)

Role of SWI in Identifying Microhemorrhages in Mild Traumatic Brain Injury
by: Lukas Kalytis, et al.
Published: (2024-12-01)

Test the Effectiveness of Mulberry Leaf Extract (Morus Nigra) Against the Inhibitory Power of Pseudomonas Sp.
by: Anik Latifah, et al.
Published: (2024-08-01)

The Discovery of Phages in the Substantia Nigra and Its Implication for Parkinson’s Disease
by: Yun Zhao, et al.
Published: (2025-01-01)