Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation
The docking proteins of the Grb2-associated binder (Gab) family have emerged as crucial signaling compartments in metazoans. In mammals, the Gab proteins, consisting of Gab1, Gab2, and Gab3, are involved in the amplification and integration of signal transduction evoked by a variety of extracellular...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/141068 |
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| _version_ | 1832553367085252608 |
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| author | Yoshikazu Nakaoka Issei Komuro |
| author_facet | Yoshikazu Nakaoka Issei Komuro |
| author_sort | Yoshikazu Nakaoka |
| collection | DOAJ |
| description | The docking proteins of the Grb2-associated binder (Gab) family have emerged as crucial signaling compartments in metazoans. In mammals, the Gab proteins, consisting of Gab1, Gab2, and Gab3, are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli, including growth factors, cytokines, antigens, and other molecules. Gab proteins lack the enzymatic activity themselves; however, when phosphorylated on tyrosine residues, they provide binding sites for multiple Src homology-2 (SH2) domain-containing proteins, such as SH2-containing protein tyrosine phosphatase 2 (SHP2), phosphatidylinositol 3-kinase regulatory subunit p85, phospholipase Cγ, Crk, and GC-GAP. Through these interactions, the Gab proteins transduce signals from activated receptors into pathways with distinct biological functions, thereby contributing to signal diversification. They are known to play crucial roles in numerous physiological processes through their associations with SHP2 and p85. In addition, abnormal Gab protein signaling has been linked to human diseases including cancer, cardiovascular disease, and inflammatory disorders. In this paper, we provide an overview of the structure, effector functions, and regulation of the Gab docking proteins, with a special focus on their associations with cardiovascular disease, cancer, and inflammation. |
| format | Article |
| id | doaj-art-eac52bcb11734213bbb41d0ac4bcfbae |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-eac52bcb11734213bbb41d0ac4bcfbae2025-02-03T05:54:17ZengWileyInternational Journal of Inflammation2090-80402042-00992013-01-01201310.1155/2013/141068141068Gab Docking Proteins in Cardiovascular Disease, Cancer, and InflammationYoshikazu Nakaoka0Issei Komuro1Department of Cardiovascular Medicine, Graduate School of Medicine Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanThe docking proteins of the Grb2-associated binder (Gab) family have emerged as crucial signaling compartments in metazoans. In mammals, the Gab proteins, consisting of Gab1, Gab2, and Gab3, are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli, including growth factors, cytokines, antigens, and other molecules. Gab proteins lack the enzymatic activity themselves; however, when phosphorylated on tyrosine residues, they provide binding sites for multiple Src homology-2 (SH2) domain-containing proteins, such as SH2-containing protein tyrosine phosphatase 2 (SHP2), phosphatidylinositol 3-kinase regulatory subunit p85, phospholipase Cγ, Crk, and GC-GAP. Through these interactions, the Gab proteins transduce signals from activated receptors into pathways with distinct biological functions, thereby contributing to signal diversification. They are known to play crucial roles in numerous physiological processes through their associations with SHP2 and p85. In addition, abnormal Gab protein signaling has been linked to human diseases including cancer, cardiovascular disease, and inflammatory disorders. In this paper, we provide an overview of the structure, effector functions, and regulation of the Gab docking proteins, with a special focus on their associations with cardiovascular disease, cancer, and inflammation.http://dx.doi.org/10.1155/2013/141068 |
| spellingShingle | Yoshikazu Nakaoka Issei Komuro Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation International Journal of Inflammation |
| title | Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation |
| title_full | Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation |
| title_fullStr | Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation |
| title_full_unstemmed | Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation |
| title_short | Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation |
| title_sort | gab docking proteins in cardiovascular disease cancer and inflammation |
| url | http://dx.doi.org/10.1155/2013/141068 |
| work_keys_str_mv | AT yoshikazunakaoka gabdockingproteinsincardiovasculardiseasecancerandinflammation AT isseikomuro gabdockingproteinsincardiovasculardiseasecancerandinflammation |