Surface Display of Type 1 Fimbriae on <i>Shigella flexneri</i> Induces Antigen-Specific Immune Response via Oral Route

Surface Display of Type 1 Fimbriae on <i>Shigella flexneri</i> Induces Antigen-Specific Immune Response via Oral Route

Background: Live attenuated bacteria are promising candidates for mucosal vaccine delivery due to their ability to elicit robust immune responses. FimH is the adhesion protein of type 1 fimbriae, which is used as mucosal adjuvants. This study aims to develop a novel attenuated live bacterial vector...

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Bibliographic Details
Main Authors: Shuli Sang, Rui Yu, Yunyun Mao, Yanfang Zhai, Chen Cao, Kai Li, Yiyan Guan, Haoxia Tao, Chunjie Liu, Yanchun Wang
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Vaccines
Subjects:
type 1 fimbriae
attenuated bacterial vector
<i>Shigella flexneri</i>
Online Access:https://www.mdpi.com/2076-393X/13/3/280
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