Photobiomodulation in ocular therapy: current status and future perspectives
Photobiomodulation has been known to have potential medicinal effects for ages. It involves the use of specific wavelengths to target specific regions in the cell. Different health conditions have been reported to be treated with exposure to light such as cardiovascular conditions, inflammatory dise...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-02-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/2/20250220.pdf |
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| author | Hasan Chichan Iftkhar Hamzah Aldujaly Konstantinos Michalakis Levent Kanal |
| author_facet | Hasan Chichan Iftkhar Hamzah Aldujaly Konstantinos Michalakis Levent Kanal |
| author_sort | Hasan Chichan |
| collection | DOAJ |
| description | Photobiomodulation has been known to have potential medicinal effects for ages. It involves the use of specific wavelengths to target specific regions in the cell. Different health conditions have been reported to be treated with exposure to light such as cardiovascular conditions, inflammatory diseases, infectious diseases, and most importantly ocular diseases. This review specifically targets the treatment of retinal diseases including age-related macular degeneration, diabetic macular edema, myopia and acute retinal light injury with photobiomodulation. Red light is used in this therapy since this wavelength has lower frequency and hence minimal chance of causing any damage. Red light has the potential to penetrate cellular structures such as mitochondria and facilitate cellular processes. For ocular diseases, the target wavelength ranges between 630 to 800 nm. In most of the cases the primary target for red light is the cytochrome C oxidase enzyme in mitochondria, which alters the gene expression and promotes cellular energy production. Clinical evidence shows improvement of visual activity and reduction in thickness of retina post treatment. Future prospects of photobiomodulation involve target-specific treatment, combinational therapy to treat complex retinal diseases including gene therapy, and longitudinal studies to predict long-term efficacy and the chance of any recurrence in the patients. Hence the future of photobiomodulation holds significant potential in medicine especially in ocular diseases characterized by progress in research, technology, and clinical trials. |
| format | Article |
| id | doaj-art-eac0f20fcfd04a828a85708b2cdfc23f |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-eac0f20fcfd04a828a85708b2cdfc23f2025-01-16T07:54:35ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-02-0118235135710.18240/ijo.2025.02.2020250220Photobiomodulation in ocular therapy: current status and future perspectivesHasan Chichan0Iftkhar Hamzah Aldujaly1Konstantinos Michalakis2Levent Kanal3Hasan Chichan. Al-Mustaqbal University, College of Science, Hillah 51001, Babylon, Iraq. Chichan@Lumedico.comAl-Mustaqbal University, College of Science, Hillah 51001, Babylon, IraqLumedico Eye Clinics Düsseldorf Germany, Münsterstraße 96, Düsseldorf 40476, GermanyLumedico Eye Clinics Düsseldorf Germany, Münsterstraße 96, Düsseldorf 40476, GermanyPhotobiomodulation has been known to have potential medicinal effects for ages. It involves the use of specific wavelengths to target specific regions in the cell. Different health conditions have been reported to be treated with exposure to light such as cardiovascular conditions, inflammatory diseases, infectious diseases, and most importantly ocular diseases. This review specifically targets the treatment of retinal diseases including age-related macular degeneration, diabetic macular edema, myopia and acute retinal light injury with photobiomodulation. Red light is used in this therapy since this wavelength has lower frequency and hence minimal chance of causing any damage. Red light has the potential to penetrate cellular structures such as mitochondria and facilitate cellular processes. For ocular diseases, the target wavelength ranges between 630 to 800 nm. In most of the cases the primary target for red light is the cytochrome C oxidase enzyme in mitochondria, which alters the gene expression and promotes cellular energy production. Clinical evidence shows improvement of visual activity and reduction in thickness of retina post treatment. Future prospects of photobiomodulation involve target-specific treatment, combinational therapy to treat complex retinal diseases including gene therapy, and longitudinal studies to predict long-term efficacy and the chance of any recurrence in the patients. Hence the future of photobiomodulation holds significant potential in medicine especially in ocular diseases characterized by progress in research, technology, and clinical trials.http://ies.ijo.cn/en_publish/2025/2/20250220.pdfphotobiomodulationretinanear-infraredocular diseaseslight therapy |
| spellingShingle | Hasan Chichan Iftkhar Hamzah Aldujaly Konstantinos Michalakis Levent Kanal Photobiomodulation in ocular therapy: current status and future perspectives International Journal of Ophthalmology photobiomodulation retina near-infrared ocular diseases light therapy |
| title | Photobiomodulation in ocular therapy: current status and future perspectives |
| title_full | Photobiomodulation in ocular therapy: current status and future perspectives |
| title_fullStr | Photobiomodulation in ocular therapy: current status and future perspectives |
| title_full_unstemmed | Photobiomodulation in ocular therapy: current status and future perspectives |
| title_short | Photobiomodulation in ocular therapy: current status and future perspectives |
| title_sort | photobiomodulation in ocular therapy current status and future perspectives |
| topic | photobiomodulation retina near-infrared ocular diseases light therapy |
| url | http://ies.ijo.cn/en_publish/2025/2/20250220.pdf |
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