Expansion of white matter hyperintensities is associated with the glymphatic system dysfunction in cerebral small vessel disease
Objectives: To explore the relationship between the glymphatic system and various patterns of white matter hyperintensities (WMHs) in the early stages of cerebral small vessel disease (CSVD), as well as their impact on cognitive function. Methods: The report included 84 patients with CSVD and 23 hea...
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Elsevier
2025-07-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025002035 |
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| author | Bang Zeng Peng Zeng Yayun Xiang Yuling Peng Dan Luo Binglan Li Ying Chai Dan Wang Lisha Nie Yongmei Li |
| author_facet | Bang Zeng Peng Zeng Yayun Xiang Yuling Peng Dan Luo Binglan Li Ying Chai Dan Wang Lisha Nie Yongmei Li |
| author_sort | Bang Zeng |
| collection | DOAJ |
| description | Objectives: To explore the relationship between the glymphatic system and various patterns of white matter hyperintensities (WMHs) in the early stages of cerebral small vessel disease (CSVD), as well as their impact on cognitive function. Methods: The report included 84 patients with CSVD and 23 healthy controls (HCs). To comprehensively assess the impact of white matter hyperintensity volume (WMHV) and WMH counts, we introduced the mean WMHV (WMHV/count) as a new biomarker. Using a threshold of 0.1 for mean WMHV, we categorized participants into two groups to compare intergroup differences. The metrics of the glymphatic system included the index of diffusivity along the perivascular space (Analysis aLong the Perivascular Space [ALPS] index) and the fractional volume of free water (FW). Finally, we analyzed the correlations between imaging indicators and cognitive scales using linear regression models. Results: Compared to HC and Group 1 (mean WMHV ≤ 0.1), Group 2 (mean WMHV > 0.1) exhibited a lower ALPS index and higher fractional volume of FW across various brain regions, including the whole brain (FW-ALL), white matter (FW-WM), basal ganglia (FW-BG), and hippocampus (FW-Hipp). In a correlation analysis, the mean WMHV showed significant correlations with FW-ALL, FW-WM, and FW-BG. Meanwhile, WMHV was only correlated with FW-BG. Furthermore, both FW-BG and the ALPS index were associated with Digit Symbol Substitution Test scores. Conclusions: Mean WMHV can reflect the confluence and expansion of WMH and is closely associated with glymphatic system disfunction. |
| format | Article |
| id | doaj-art-eac04b8db125433287730265513fab7f |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-eac04b8db125433287730265513fab7f2025-08-20T03:25:47ZengElsevierBrain Research Bulletin1873-27472025-07-0122711139110.1016/j.brainresbull.2025.111391Expansion of white matter hyperintensities is associated with the glymphatic system dysfunction in cerebral small vessel diseaseBang Zeng0Peng Zeng1Yayun Xiang2Yuling Peng3Dan Luo4Binglan Li5Ying Chai6Dan Wang7Lisha Nie8Yongmei Li9Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, China; Department of Radiology, People's Hospital of Shapingba District, 44# Xiaolongkan New Street, Chongqing 400010, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, China; Department of Radiology, People's Hospital of Shapingba District, 44# Xiaolongkan New Street, Chongqing 400010, ChinaDepartment of Radiology, Mianyang Central Hospital, 12# Changjia Lane, Mianyang 621000, China; GE Healthcare, MR Research China, Beijing 100076, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, 1# Youyi Road, Yuan Jiagang, Chongqing 400010, China; Corresponding author.Objectives: To explore the relationship between the glymphatic system and various patterns of white matter hyperintensities (WMHs) in the early stages of cerebral small vessel disease (CSVD), as well as their impact on cognitive function. Methods: The report included 84 patients with CSVD and 23 healthy controls (HCs). To comprehensively assess the impact of white matter hyperintensity volume (WMHV) and WMH counts, we introduced the mean WMHV (WMHV/count) as a new biomarker. Using a threshold of 0.1 for mean WMHV, we categorized participants into two groups to compare intergroup differences. The metrics of the glymphatic system included the index of diffusivity along the perivascular space (Analysis aLong the Perivascular Space [ALPS] index) and the fractional volume of free water (FW). Finally, we analyzed the correlations between imaging indicators and cognitive scales using linear regression models. Results: Compared to HC and Group 1 (mean WMHV ≤ 0.1), Group 2 (mean WMHV > 0.1) exhibited a lower ALPS index and higher fractional volume of FW across various brain regions, including the whole brain (FW-ALL), white matter (FW-WM), basal ganglia (FW-BG), and hippocampus (FW-Hipp). In a correlation analysis, the mean WMHV showed significant correlations with FW-ALL, FW-WM, and FW-BG. Meanwhile, WMHV was only correlated with FW-BG. Furthermore, both FW-BG and the ALPS index were associated with Digit Symbol Substitution Test scores. Conclusions: Mean WMHV can reflect the confluence and expansion of WMH and is closely associated with glymphatic system disfunction.http://www.sciencedirect.com/science/article/pii/S0361923025002035Cerebral small vessel diseaseWhite matter hyperintensitiesGlymphatic system |
| spellingShingle | Bang Zeng Peng Zeng Yayun Xiang Yuling Peng Dan Luo Binglan Li Ying Chai Dan Wang Lisha Nie Yongmei Li Expansion of white matter hyperintensities is associated with the glymphatic system dysfunction in cerebral small vessel disease Brain Research Bulletin Cerebral small vessel disease White matter hyperintensities Glymphatic system |
| title | Expansion of white matter hyperintensities is associated with the glymphatic system dysfunction in cerebral small vessel disease |
| title_full | Expansion of white matter hyperintensities is associated with the glymphatic system dysfunction in cerebral small vessel disease |
| title_fullStr | Expansion of white matter hyperintensities is associated with the glymphatic system dysfunction in cerebral small vessel disease |
| title_full_unstemmed | Expansion of white matter hyperintensities is associated with the glymphatic system dysfunction in cerebral small vessel disease |
| title_short | Expansion of white matter hyperintensities is associated with the glymphatic system dysfunction in cerebral small vessel disease |
| title_sort | expansion of white matter hyperintensities is associated with the glymphatic system dysfunction in cerebral small vessel disease |
| topic | Cerebral small vessel disease White matter hyperintensities Glymphatic system |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025002035 |
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