HLA types in Turkish children with celiac disease
The aim of this study was to assess the distribution of human leukocyte antigen (HLA) groups in Turkish children with celiac disease (CD) and to investigate the association of HLA types and clinical manifestations of CD. Seventy-five children with CD were evaluated in two groups: Group I cons...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
2008-12-01
|
| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2482 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850041705007415296 |
|---|---|
| author | Zarife Kuloğlu Tümay Doğanci Aydan Kansu Fulya Demirçeken Murat Duman Hüseyin Tutkak Arzu Ensari Nurten Girgin |
| author_facet | Zarife Kuloğlu Tümay Doğanci Aydan Kansu Fulya Demirçeken Murat Duman Hüseyin Tutkak Arzu Ensari Nurten Girgin |
| author_sort | Zarife Kuloğlu |
| collection | DOAJ |
| description |
The aim of this study was to assess the distribution of human leukocyte antigen (HLA) groups in Turkish children with celiac disease (CD) and to investigate the association of HLA types and clinical manifestations of CD. Seventy-five children with CD were evaluated in two groups: Group I consisted of 45 classical celiac patients (15 males, 6.7+/-3.8 years); Group II consisted of 30 atypical celiac patients (9 males, 9.3+/-4.3 years). The control group consisted of 100 healthy renal transplantation donors. HLA typing was made serologically using standard lymphocytotoxicity techniques. HLA A29, B51, CW5, DR14, DR16, and DQ1 were the most common antigens in the control group. Frequency of HLA B13, CW7, B8, DR7, DR17 and DQ2 was higher in CD patients than in the control group (p |
| format | Article |
| id | doaj-art-eaba13c8a69740da8871404867163a9b |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2008-12-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-eaba13c8a69740da8871404867163a9b2025-08-20T02:55:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212008-12-01506HLA types in Turkish children with celiac diseaseZarife Kuloğlu0Tümay DoğanciAydan KansuFulya DemirçekenMurat DumanHüseyin TutkakArzu EnsariNurten GirginDepartment of Pediatric Gastroenterology, Ankara University Faculty of Medicine, Ankara, Turkey. The aim of this study was to assess the distribution of human leukocyte antigen (HLA) groups in Turkish children with celiac disease (CD) and to investigate the association of HLA types and clinical manifestations of CD. Seventy-five children with CD were evaluated in two groups: Group I consisted of 45 classical celiac patients (15 males, 6.7+/-3.8 years); Group II consisted of 30 atypical celiac patients (9 males, 9.3+/-4.3 years). The control group consisted of 100 healthy renal transplantation donors. HLA typing was made serologically using standard lymphocytotoxicity techniques. HLA A29, B51, CW5, DR14, DR16, and DQ1 were the most common antigens in the control group. Frequency of HLA B13, CW7, B8, DR7, DR17 and DQ2 was higher in CD patients than in the control group (phttps://turkjpediatr.org/article/view/2482 |
| spellingShingle | Zarife Kuloğlu Tümay Doğanci Aydan Kansu Fulya Demirçeken Murat Duman Hüseyin Tutkak Arzu Ensari Nurten Girgin HLA types in Turkish children with celiac disease The Turkish Journal of Pediatrics |
| title | HLA types in Turkish children with celiac disease |
| title_full | HLA types in Turkish children with celiac disease |
| title_fullStr | HLA types in Turkish children with celiac disease |
| title_full_unstemmed | HLA types in Turkish children with celiac disease |
| title_short | HLA types in Turkish children with celiac disease |
| title_sort | hla types in turkish children with celiac disease |
| url | https://turkjpediatr.org/article/view/2482 |
| work_keys_str_mv | AT zarifekuloglu hlatypesinturkishchildrenwithceliacdisease AT tumaydoganci hlatypesinturkishchildrenwithceliacdisease AT aydankansu hlatypesinturkishchildrenwithceliacdisease AT fulyademirceken hlatypesinturkishchildrenwithceliacdisease AT muratduman hlatypesinturkishchildrenwithceliacdisease AT huseyintutkak hlatypesinturkishchildrenwithceliacdisease AT arzuensari hlatypesinturkishchildrenwithceliacdisease AT nurtengirgin hlatypesinturkishchildrenwithceliacdisease |