iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia

iPSC-derived NK cells engineered with CD226 effectively control acute myeloid leukemia

Abstract CD226 plays a vital role in NK cell cytotoxicity, interacting with its ligands on tumor targets. Acute myeloid leukemia (AML) cells have developed mechanisms to escape NK cell cytotoxicity, including inducing downregulation of CD226 on NK cells. Induced pluripotent stem cell -derived NK (iP...

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Bibliographic Details
Main Authors: Runze Cai, Binyan Lu, Xiangyu Zhao, Shixin Zhou, Yang Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Experimental Hematology & Oncology
Subjects:
Acute myeloid leukemia
iPSC-derived NK cells
CD226
Immunotherapy
Online Access:https://doi.org/10.1186/s40164-025-00686-9
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