Amino acid substitutions in human growth hormone affect secondary structure and receptor binding.

Amino acid substitutions in human growth hormone affect secondary structure and receptor binding.

The interaction between human Growth Hormone (hGH) and hGH Receptor (hGHR) has basic relevance to cancer and growth disorders, and hGH is the scaffold for Pegvisomant, an anti-acromegaly therapeutic. For the latter reason, hGH has been extensively engineered by early workers to improve binding and o...

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Bibliographic Details
Main Authors: Andrei Rajkovic, Sandesh Kanchugal, Eldar Abdurakhmanov, Rebecca Howard, Sebastian Wärmländer, Joseph Erwin, Hugo A Barrera Saldaña, Astrid Gräslund, Helena Danielson, Samuel Coulbourn Flores
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0282741&type=printable
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