Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents
Objective. To evaluate leptin and adiponectin as biomarkers of metabolic syndrome (MS) risk factors even in nonobese children/adolescents. Methods. Serum leptin, adiponectin, leptin:adiponectin ratio, lipids, glucose, and insulin concentrations as well as body size parameters and pubertal developmen...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2010/892081 |
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| author | Jie Mi Mercedes Nancy Munkonda Ming Li Mei-Xian Zhang Xiao-Yuan Zhao Ponce Cedric Wamba Fouejeu Katherine Cianflone |
| author_facet | Jie Mi Mercedes Nancy Munkonda Ming Li Mei-Xian Zhang Xiao-Yuan Zhao Ponce Cedric Wamba Fouejeu Katherine Cianflone |
| author_sort | Jie Mi |
| collection | DOAJ |
| description | Objective. To evaluate leptin and adiponectin as biomarkers of metabolic syndrome (MS) risk factors even in nonobese children/adolescents. Methods. Serum leptin, adiponectin, leptin:adiponectin ratio, lipids, glucose, and insulin concentrations as well as body size parameters and pubertal development were evaluated in a large population of Chinese children/adolescents (n=3505, 6–18 years, 1722 girls and 1783 boys). Results. Leptin concentration increased while adiponectin decreased with obesity, both were influenced by pubertal development. Central obesity had an additive effect on leptin levels (above obesity alone). Leptin/adiponectin increased 8.4-fold and 3.2-fold in overweight/obesity, and 15.8- and 4.5-fold with obesity plus MS, in early and late puberty, respectively. Even in normal weight children/adolescents, higher leptin and lower adiponectin concentrations associated with increased risk profile. Conversely, overweight/obese with lower leptin or higher adiponectin concentrations had a less compromised metabolic profile. Conclusion. Leptin, adiponectin, and leptin:adiponectin ratio are informative biomarkers for obesity, central obesity, MS, and abnormal metabolic profile even in normal weight children/adolescents. |
| format | Article |
| id | doaj-art-eab56e41a0904e5b84c2b882cd8f932c |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-eab56e41a0904e5b84c2b882cd8f932c2025-02-03T01:33:13ZengWileyJournal of Obesity2090-07082090-07162010-01-01201010.1155/2010/892081892081Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and AdolescentsJie Mi0Mercedes Nancy Munkonda1Ming Li2Mei-Xian Zhang3Xiao-Yuan Zhao4Ponce Cedric Wamba Fouejeu5Katherine Cianflone6Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaCentre de Recherche Institut, Universitaire de Cardiologie et Pneumologie de Quebec, Université Laval, 2725 Chemin Ste-Foy, Québec, QC, G1V 4G5, CanadaDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, ChinaDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, ChinaLaboratory of Nutrition and Nutritional Biochemistry, University of Yaoundé, Yaoundé, CameroonDepartment of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaObjective. To evaluate leptin and adiponectin as biomarkers of metabolic syndrome (MS) risk factors even in nonobese children/adolescents. Methods. Serum leptin, adiponectin, leptin:adiponectin ratio, lipids, glucose, and insulin concentrations as well as body size parameters and pubertal development were evaluated in a large population of Chinese children/adolescents (n=3505, 6–18 years, 1722 girls and 1783 boys). Results. Leptin concentration increased while adiponectin decreased with obesity, both were influenced by pubertal development. Central obesity had an additive effect on leptin levels (above obesity alone). Leptin/adiponectin increased 8.4-fold and 3.2-fold in overweight/obesity, and 15.8- and 4.5-fold with obesity plus MS, in early and late puberty, respectively. Even in normal weight children/adolescents, higher leptin and lower adiponectin concentrations associated with increased risk profile. Conversely, overweight/obese with lower leptin or higher adiponectin concentrations had a less compromised metabolic profile. Conclusion. Leptin, adiponectin, and leptin:adiponectin ratio are informative biomarkers for obesity, central obesity, MS, and abnormal metabolic profile even in normal weight children/adolescents.http://dx.doi.org/10.1155/2010/892081 |
| spellingShingle | Jie Mi Mercedes Nancy Munkonda Ming Li Mei-Xian Zhang Xiao-Yuan Zhao Ponce Cedric Wamba Fouejeu Katherine Cianflone Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents Journal of Obesity |
| title | Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents |
| title_full | Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents |
| title_fullStr | Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents |
| title_full_unstemmed | Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents |
| title_short | Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents |
| title_sort | adiponectin and leptin metabolic biomarkers in chinese children and adolescents |
| url | http://dx.doi.org/10.1155/2010/892081 |
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