Treatment for rheumatic polymyalgia
Glucocorticosteroids (GCs) that provide a good and rapid clinical effect are the drug of choice to treat rheumatic polymyalgia (RP). A review of English language publications on the treatment of RP is given. Thirty (13 randomized and 17 observational) studies of 20 and more patients with RP have bee...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2013-03-01
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| Series: | Современная ревматология |
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| Online Access: | https://mrj.ima-press.net/mrj/article/view/469 |
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| author | Azamat Makhmudovich Satybaldyev |
| author_facet | Azamat Makhmudovich Satybaldyev |
| author_sort | Azamat Makhmudovich Satybaldyev |
| collection | DOAJ |
| description | Glucocorticosteroids (GCs) that provide a good and rapid clinical effect are the drug of choice to treat rheumatic polymyalgia (RP). A review of English language publications on the treatment of RP is given. Thirty (13 randomized and 17 observational) studies of 20 and more patients with RP have been analyzed. Particular emphasis is laid on initial therapy with GCs, evaluation of their different daily doses, schemes for their dosage reduction and treatment termination, and on the frequency of recurrences. Studies dealing with the treatment with prednisone, prednisolone, methylprednisolone, and injectable sustained-release GC formulations are considered. The data of clinical trials of glucocorticoid-sparing agents (methotrexate, azathioprine) during early and maintenance therapy are analyzed. The genetically engineered agents (infliximab, etanercept) investigated in clinical trials are considered to be as alternatives; a case of using rituximab is described. The role of nonsteroidal anti-inflammatory drugs in the treatment of RP is also evaluated. An algorithm is proposed for the management of a patient with RP. |
| format | Article |
| id | doaj-art-eab2d855632441d188dada6b2caf2edd |
| institution | Kabale University |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2013-03-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-eab2d855632441d188dada6b2caf2edd2025-08-20T03:59:57ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2013-03-0171667210.14412/1996-7012-2013-23711774Treatment for rheumatic polymyalgiaAzamat Makhmudovich SatybaldyevGlucocorticosteroids (GCs) that provide a good and rapid clinical effect are the drug of choice to treat rheumatic polymyalgia (RP). A review of English language publications on the treatment of RP is given. Thirty (13 randomized and 17 observational) studies of 20 and more patients with RP have been analyzed. Particular emphasis is laid on initial therapy with GCs, evaluation of their different daily doses, schemes for their dosage reduction and treatment termination, and on the frequency of recurrences. Studies dealing with the treatment with prednisone, prednisolone, methylprednisolone, and injectable sustained-release GC formulations are considered. The data of clinical trials of glucocorticoid-sparing agents (methotrexate, azathioprine) during early and maintenance therapy are analyzed. The genetically engineered agents (infliximab, etanercept) investigated in clinical trials are considered to be as alternatives; a case of using rituximab is described. The role of nonsteroidal anti-inflammatory drugs in the treatment of RP is also evaluated. An algorithm is proposed for the management of a patient with RP.https://mrj.ima-press.net/mrj/article/view/469rheumatic polymyalgiaglucocorticosteroidsprednisoneprednisolonemethyl-prednisolonedeflazacortmethotrexateazathioprinenonsteroidal anti-inflammatory drugsbiological therapy |
| spellingShingle | Azamat Makhmudovich Satybaldyev Treatment for rheumatic polymyalgia Современная ревматология rheumatic polymyalgia glucocorticosteroids prednisone prednisolone methyl-prednisolone deflazacort methotrexate azathioprine nonsteroidal anti-inflammatory drugs biological therapy |
| title | Treatment for rheumatic polymyalgia |
| title_full | Treatment for rheumatic polymyalgia |
| title_fullStr | Treatment for rheumatic polymyalgia |
| title_full_unstemmed | Treatment for rheumatic polymyalgia |
| title_short | Treatment for rheumatic polymyalgia |
| title_sort | treatment for rheumatic polymyalgia |
| topic | rheumatic polymyalgia glucocorticosteroids prednisone prednisolone methyl-prednisolone deflazacort methotrexate azathioprine nonsteroidal anti-inflammatory drugs biological therapy |
| url | https://mrj.ima-press.net/mrj/article/view/469 |
| work_keys_str_mv | AT azamatmakhmudovichsatybaldyev treatmentforrheumaticpolymyalgia |