Peripheral nerve injury recovery enhanced by ceftriaxone: a preclinical investigation
ABSTRACT Purpose: To evaluate ceftriaxone’s potential in enhancing peripheral nerve injuries (PNIs) recovery. Methods: Thirty male Wistar rats were divided into control (no surgery), vehicle (sciatic nerve injury + 0.9% NaCl), and ceftriaxone (sciatic nerve injury + 50 mg/kg/day ceftriaxone) group...
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| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2025-07-01
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| Series: | Acta Cirúrgica Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100228&lng=en&tlng=en |
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| author | Berkin Gunar Ejder Saylav Bora Osman Mert Topkar Özgür Baysal Ziya Shammadli Oytun Erbas |
| author_facet | Berkin Gunar Ejder Saylav Bora Osman Mert Topkar Özgür Baysal Ziya Shammadli Oytun Erbas |
| author_sort | Berkin Gunar |
| collection | DOAJ |
| description | ABSTRACT Purpose: To evaluate ceftriaxone’s potential in enhancing peripheral nerve injuries (PNIs) recovery. Methods: Thirty male Wistar rats were divided into control (no surgery), vehicle (sciatic nerve injury + 0.9% NaCl), and ceftriaxone (sciatic nerve injury + 50 mg/kg/day ceftriaxone) groups. Treatments were administered intraperitoneally for 12 weeks. Functional recovery was assessed using inclined plane tests and electromyography. Sciatic nerve regeneration was evaluated via histology, nerve growth factor (NGF) immunohistochemistry, and enzyme-linked immunosorbent assay. Results: Compared to the control group, inclined plane test scores, nerve action potentials, NGF expression, axon counts, and diameters were diminished in both injury groups (p 0.001). However, these parameters were significantly improved in the ceftriaxone group compared to the vehicle group (p 0.001). Increased fibrosis was observed in the ceftriaxone group. Conclusion: Ceftriaxone demonstrates potential as a pharmacological agent for PNI recovery by enhancing nerve regeneration and functional outcomes. Further studies are warranted to elucidate its mechanisms. |
| format | Article |
| id | doaj-art-eab24903a20e4996a6faef2938e539b3 |
| institution | Kabale University |
| issn | 1678-2674 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj-art-eab24903a20e4996a6faef2938e539b32025-08-20T03:29:58ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira1678-26742025-07-014010.1590/acb404625Peripheral nerve injury recovery enhanced by ceftriaxone: a preclinical investigationBerkin Gunarhttps://orcid.org/0000-0001-9409-1510Ejder Saylav Borahttps://orcid.org/0000-0002-2448-2337Osman Mert Topkarhttps://orcid.org/0000-0003-2452-1954Özgür Baysalhttps://orcid.org/0000-0001-5150-8857Ziya Shammadlihttps://orcid.org/0000-0003-1501-0108Oytun Erbashttps://orcid.org/0000-0001-5427-8428ABSTRACT Purpose: To evaluate ceftriaxone’s potential in enhancing peripheral nerve injuries (PNIs) recovery. Methods: Thirty male Wistar rats were divided into control (no surgery), vehicle (sciatic nerve injury + 0.9% NaCl), and ceftriaxone (sciatic nerve injury + 50 mg/kg/day ceftriaxone) groups. Treatments were administered intraperitoneally for 12 weeks. Functional recovery was assessed using inclined plane tests and electromyography. Sciatic nerve regeneration was evaluated via histology, nerve growth factor (NGF) immunohistochemistry, and enzyme-linked immunosorbent assay. Results: Compared to the control group, inclined plane test scores, nerve action potentials, NGF expression, axon counts, and diameters were diminished in both injury groups (p 0.001). However, these parameters were significantly improved in the ceftriaxone group compared to the vehicle group (p 0.001). Increased fibrosis was observed in the ceftriaxone group. Conclusion: Ceftriaxone demonstrates potential as a pharmacological agent for PNI recovery by enhancing nerve regeneration and functional outcomes. Further studies are warranted to elucidate its mechanisms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100228&lng=en&tlng=enNerve Growth FactorsCeftriaxoneExperimental Study |
| spellingShingle | Berkin Gunar Ejder Saylav Bora Osman Mert Topkar Özgür Baysal Ziya Shammadli Oytun Erbas Peripheral nerve injury recovery enhanced by ceftriaxone: a preclinical investigation Acta Cirúrgica Brasileira Nerve Growth Factors Ceftriaxone Experimental Study |
| title | Peripheral nerve injury recovery enhanced by ceftriaxone: a preclinical investigation |
| title_full | Peripheral nerve injury recovery enhanced by ceftriaxone: a preclinical investigation |
| title_fullStr | Peripheral nerve injury recovery enhanced by ceftriaxone: a preclinical investigation |
| title_full_unstemmed | Peripheral nerve injury recovery enhanced by ceftriaxone: a preclinical investigation |
| title_short | Peripheral nerve injury recovery enhanced by ceftriaxone: a preclinical investigation |
| title_sort | peripheral nerve injury recovery enhanced by ceftriaxone a preclinical investigation |
| topic | Nerve Growth Factors Ceftriaxone Experimental Study |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100228&lng=en&tlng=en |
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