Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.
Hemidesmosomes are composed of intricate networks of proteins, that are an essential attachment apparatus for the integrity of epithelial tissue. Disruption leads to blistering diseases such as epidermolysis bullosa. Members of the Sox gene family show dynamic and diverse expression patterns during...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043857&type=printable |
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| author | Shelly Oommen Mathias Francois Maiko Kawasaki Melanie Murrell Katsushige Kawasaki Thantrira Porntaveetus Sarah Ghafoor Neville J Young Yoshimasa Okamatsu John McGrath Peter Koopman Paul T Sharpe Atsushi Ohazama |
| author_facet | Shelly Oommen Mathias Francois Maiko Kawasaki Melanie Murrell Katsushige Kawasaki Thantrira Porntaveetus Sarah Ghafoor Neville J Young Yoshimasa Okamatsu John McGrath Peter Koopman Paul T Sharpe Atsushi Ohazama |
| author_sort | Shelly Oommen |
| collection | DOAJ |
| description | Hemidesmosomes are composed of intricate networks of proteins, that are an essential attachment apparatus for the integrity of epithelial tissue. Disruption leads to blistering diseases such as epidermolysis bullosa. Members of the Sox gene family show dynamic and diverse expression patterns during development and mutation analyses in humans and mice provide evidence that they play a remarkable variety of roles in development and human disease. Previous studies have established that the mouse mutant ragged-opossum (Ra(op)) expresses a dominant-negative form of the SOX18 transcription factor that interferes with the function of wild type SOX18 and of the related SOXF-subgroup proteins SOX7 and -17. Here we show that skin and oral mucosa in homozygous Ra(op) mice display extensive detachment of epithelium from the underlying mesenchymal tissue, caused by tearing of epithelial cells just above the plasma membrane due to hemidesmosome disruption. In addition, several hemidesmosome proteins expression were found to be dysregulated in the Ra(op) mice. Our data suggest that SOXF transcription factors play a role in regulating formation of cytoplasmic plaque protein assembly, and that disrupted SOXF function results in epidermolysis bullosa-like skin phenotypes. |
| format | Article |
| id | doaj-art-eaafc9ef60df4eba99720c82ba5fda46 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-eaafc9ef60df4eba99720c82ba5fda462025-08-20T03:26:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4385710.1371/journal.pone.0043857Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.Shelly OommenMathias FrancoisMaiko KawasakiMelanie MurrellKatsushige KawasakiThantrira PorntaveetusSarah GhafoorNeville J YoungYoshimasa OkamatsuJohn McGrathPeter KoopmanPaul T SharpeAtsushi OhazamaHemidesmosomes are composed of intricate networks of proteins, that are an essential attachment apparatus for the integrity of epithelial tissue. Disruption leads to blistering diseases such as epidermolysis bullosa. Members of the Sox gene family show dynamic and diverse expression patterns during development and mutation analyses in humans and mice provide evidence that they play a remarkable variety of roles in development and human disease. Previous studies have established that the mouse mutant ragged-opossum (Ra(op)) expresses a dominant-negative form of the SOX18 transcription factor that interferes with the function of wild type SOX18 and of the related SOXF-subgroup proteins SOX7 and -17. Here we show that skin and oral mucosa in homozygous Ra(op) mice display extensive detachment of epithelium from the underlying mesenchymal tissue, caused by tearing of epithelial cells just above the plasma membrane due to hemidesmosome disruption. In addition, several hemidesmosome proteins expression were found to be dysregulated in the Ra(op) mice. Our data suggest that SOXF transcription factors play a role in regulating formation of cytoplasmic plaque protein assembly, and that disrupted SOXF function results in epidermolysis bullosa-like skin phenotypes.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043857&type=printable |
| spellingShingle | Shelly Oommen Mathias Francois Maiko Kawasaki Melanie Murrell Katsushige Kawasaki Thantrira Porntaveetus Sarah Ghafoor Neville J Young Yoshimasa Okamatsu John McGrath Peter Koopman Paul T Sharpe Atsushi Ohazama Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PLoS ONE |
| title | Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. |
| title_full | Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. |
| title_fullStr | Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. |
| title_full_unstemmed | Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. |
| title_short | Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. |
| title_sort | cytoplasmic plaque formation in hemidesmosome development is dependent on soxf transcription factor function |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0043857&type=printable |
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