Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head
Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly in orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on the innovative application of 3D printing in addressing the challenges of osteonecrosis...
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000894 |
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| author | Tingting Chen Lincong Luo Jiaying Li Jiamin Li Tao Lin Mingrui Liu Hang Sang Xinyu Hong Jiahao Pu Wenhua Huang |
| author_facet | Tingting Chen Lincong Luo Jiaying Li Jiamin Li Tao Lin Mingrui Liu Hang Sang Xinyu Hong Jiahao Pu Wenhua Huang |
| author_sort | Tingting Chen |
| collection | DOAJ |
| description | Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly in orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on the innovative application of 3D printing in addressing the challenges of osteonecrosis of the femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, 3D printing offers precise localization of necrotic areas and the ability to create personalized implants. By integrating advanced biomaterials, this technology offers a promising strategy approach for early hip-preserving treatments. Additionally, 3D-printed bone tissue engineering scaffolds can mimic the natural bone environment, promoting bone regeneration and vascularization. In the future, the potential of 3D printing extends to combining with artificial intelligence for optimizing treatment plans, developing materials with enhanced bioactivity and compatibility, and translating these innovations from the laboratory to clinical practice. This review demonstrates how 3D printing technology uniquely addresses critical challenges in ONFH treatment, including insufficient vascularization, poor mechanical stability, and limited long-term success of conventional therapies. By introducing gradient porous scaffolds, bioactive material coatings, and AI-assisted design, this work outlines novel strategies to improve bone regeneration and personalized hip-preserving interventions. These advancements not only enhance treatment efficacy but also pave the way for translating laboratory findings into clinical applications. |
| format | Article |
| id | doaj-art-eaab90c383e841cba2fe17d5461f2303 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-eaab90c383e841cba2fe17d5461f23032025-02-12T05:31:41ZengElsevierMaterials Today Bio2590-00642025-04-0131101531Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral headTingting Chen0Lincong Luo1Jiaying Li2Jiamin Li3Tao Lin4Mingrui Liu5Hang Sang6Xinyu Hong7Jiahao Pu8Wenhua Huang9School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian , 350108, ChinaYue Bei People's Hospital Postdoctoral Innovation Practice Base, Southern Medical University, Guangzhou, 510515, ChinaGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong , 510515, ChinaSchool of Basic Medical Sciences, Guangdong Medical University, Dongguan, 523808, ChinaGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong , 510515, ChinaSchool of Basic Medicine, Dali University, Dali, Yunnan, 671003, ChinaGuangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong , 510515, ChinaSchool of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian , 350108, ChinaSchool of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian , 350108, ChinaSchool of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian , 350108, China; Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong , 510515, China; Corresponding author. School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, 350108, China.Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly in orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on the innovative application of 3D printing in addressing the challenges of osteonecrosis of the femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, 3D printing offers precise localization of necrotic areas and the ability to create personalized implants. By integrating advanced biomaterials, this technology offers a promising strategy approach for early hip-preserving treatments. Additionally, 3D-printed bone tissue engineering scaffolds can mimic the natural bone environment, promoting bone regeneration and vascularization. In the future, the potential of 3D printing extends to combining with artificial intelligence for optimizing treatment plans, developing materials with enhanced bioactivity and compatibility, and translating these innovations from the laboratory to clinical practice. This review demonstrates how 3D printing technology uniquely addresses critical challenges in ONFH treatment, including insufficient vascularization, poor mechanical stability, and limited long-term success of conventional therapies. By introducing gradient porous scaffolds, bioactive material coatings, and AI-assisted design, this work outlines novel strategies to improve bone regeneration and personalized hip-preserving interventions. These advancements not only enhance treatment efficacy but also pave the way for translating laboratory findings into clinical applications.http://www.sciencedirect.com/science/article/pii/S25900064250008943D printing technologyOsteonecrosis of the femoral headPersonalized treatmentBone tissue engineering scaffolds |
| spellingShingle | Tingting Chen Lincong Luo Jiaying Li Jiamin Li Tao Lin Mingrui Liu Hang Sang Xinyu Hong Jiahao Pu Wenhua Huang Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head Materials Today Bio 3D printing technology Osteonecrosis of the femoral head Personalized treatment Bone tissue engineering scaffolds |
| title | Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head |
| title_full | Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head |
| title_fullStr | Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head |
| title_full_unstemmed | Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head |
| title_short | Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head |
| title_sort | advancements in 3d printing technologies for personalized treatment of osteonecrosis of the femoral head |
| topic | 3D printing technology Osteonecrosis of the femoral head Personalized treatment Bone tissue engineering scaffolds |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000894 |
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