Conjugated oligo (phenylene vinylene) covalently linked porphyrin for sonodynamic therapy
Abstract Sonodynamic therapy (SDT) is garnering considerable attention as a promising treatment for deep‐seated tumors because of its strong tissue penetration ability, non‐invasiveness, and controllability. However, the SDT efficiency of traditional sonosensitizers including porphyrins and their de...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Smart Molecules |
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| Online Access: | https://doi.org/10.1002/smo.20240035 |
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| author | Wenhua Jia Junqing Wang Ling Li Qiong Yuan Yuze Wang Xinyi Zhang Yanli Tang |
| author_facet | Wenhua Jia Junqing Wang Ling Li Qiong Yuan Yuze Wang Xinyi Zhang Yanli Tang |
| author_sort | Wenhua Jia |
| collection | DOAJ |
| description | Abstract Sonodynamic therapy (SDT) is garnering considerable attention as a promising treatment for deep‐seated tumors because of its strong tissue penetration ability, non‐invasiveness, and controllability. However, the SDT efficiency of traditional sonosensitizers including porphyrins and their derivatives are limited due to their poor water dissolubility, high aggregation, and low reactive oxygen species (ROS) production efficiency. Consequently, it is crucial to develop novel sonosensitizers with high yields of ROS, outstanding water solubility, and good biocompatibility. Herein, we constructed a new platform for SDT based on unimolecular porphyrin derivatives OPV‐C3‐TPP. The probe OPV‐C3‐TPP was synthesized by covalently linking conjugated oligomers (OPV) with 5, 10, 15, 20‐tetra (4‐aminophenyl) porphyrin (TAPP). The introduction of OPV greatly improves the water solubility of the porphyrins and reduces the self‐aggregation of the porphyrins. In addition, OPV‐C3‐TPP has good intramolecular energy transfer efficiency, thus enhancing the yield of ROS. The experimental results show that OPV‐C3‐TPP exhibits excellent ROS generation capacity under ultrasound (US) irradiation, which leads to apoptosis and necrosis of tumor cells. In vivo tumor growth is also significantly inhibited in the OPV‐C3‐TPP + US group, exhibiting better SDT effects than TAPP. Therefore, the unimolecular OPV‐C3‐TPP can be used as a potential sonosensitizer, providing a promising SDT for deep‐tissue tumors. |
| format | Article |
| id | doaj-art-eaa9bec4c8da45af9982a1eb75051d39 |
| institution | Kabale University |
| issn | 2751-4587 2751-4595 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Smart Molecules |
| spelling | doaj-art-eaa9bec4c8da45af9982a1eb75051d392025-08-20T03:29:27ZengWileySmart Molecules2751-45872751-45952025-06-0132n/an/a10.1002/smo.20240035Conjugated oligo (phenylene vinylene) covalently linked porphyrin for sonodynamic therapyWenhua Jia0Junqing Wang1Ling Li2Qiong Yuan3Yuze Wang4Xinyi Zhang5Yanli Tang6Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an ChinaKey Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an ChinaKey Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an ChinaKey Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an ChinaKey Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an ChinaKey Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an ChinaKey Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an ChinaAbstract Sonodynamic therapy (SDT) is garnering considerable attention as a promising treatment for deep‐seated tumors because of its strong tissue penetration ability, non‐invasiveness, and controllability. However, the SDT efficiency of traditional sonosensitizers including porphyrins and their derivatives are limited due to their poor water dissolubility, high aggregation, and low reactive oxygen species (ROS) production efficiency. Consequently, it is crucial to develop novel sonosensitizers with high yields of ROS, outstanding water solubility, and good biocompatibility. Herein, we constructed a new platform for SDT based on unimolecular porphyrin derivatives OPV‐C3‐TPP. The probe OPV‐C3‐TPP was synthesized by covalently linking conjugated oligomers (OPV) with 5, 10, 15, 20‐tetra (4‐aminophenyl) porphyrin (TAPP). The introduction of OPV greatly improves the water solubility of the porphyrins and reduces the self‐aggregation of the porphyrins. In addition, OPV‐C3‐TPP has good intramolecular energy transfer efficiency, thus enhancing the yield of ROS. The experimental results show that OPV‐C3‐TPP exhibits excellent ROS generation capacity under ultrasound (US) irradiation, which leads to apoptosis and necrosis of tumor cells. In vivo tumor growth is also significantly inhibited in the OPV‐C3‐TPP + US group, exhibiting better SDT effects than TAPP. Therefore, the unimolecular OPV‐C3‐TPP can be used as a potential sonosensitizer, providing a promising SDT for deep‐tissue tumors.https://doi.org/10.1002/smo.20240035antitumor agentsconjugated oligomerporphyrinsensitizerssonodynamic therapy |
| spellingShingle | Wenhua Jia Junqing Wang Ling Li Qiong Yuan Yuze Wang Xinyi Zhang Yanli Tang Conjugated oligo (phenylene vinylene) covalently linked porphyrin for sonodynamic therapy Smart Molecules antitumor agents conjugated oligomer porphyrin sensitizers sonodynamic therapy |
| title | Conjugated oligo (phenylene vinylene) covalently linked porphyrin for sonodynamic therapy |
| title_full | Conjugated oligo (phenylene vinylene) covalently linked porphyrin for sonodynamic therapy |
| title_fullStr | Conjugated oligo (phenylene vinylene) covalently linked porphyrin for sonodynamic therapy |
| title_full_unstemmed | Conjugated oligo (phenylene vinylene) covalently linked porphyrin for sonodynamic therapy |
| title_short | Conjugated oligo (phenylene vinylene) covalently linked porphyrin for sonodynamic therapy |
| title_sort | conjugated oligo phenylene vinylene covalently linked porphyrin for sonodynamic therapy |
| topic | antitumor agents conjugated oligomer porphyrin sensitizers sonodynamic therapy |
| url | https://doi.org/10.1002/smo.20240035 |
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