Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer
Abstract Photo‐responsive/activable nanomedicine‐driven therapies have emerged as a transformative approach to effectively target and eliminate tumors across different types of solid cancers. When synergistically combined with immunomodulators, these therapies significantly enhance anti‐cancer effic...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202417657 |
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| author | Deepak S. Chauhan Kun Shao Roopa Hebbandi Nanjundappa Daniel‐Jiajun Yu Marianne Stanford Huile Gao Channakeshava Sokke Umeshappa |
| author_facet | Deepak S. Chauhan Kun Shao Roopa Hebbandi Nanjundappa Daniel‐Jiajun Yu Marianne Stanford Huile Gao Channakeshava Sokke Umeshappa |
| author_sort | Deepak S. Chauhan |
| collection | DOAJ |
| description | Abstract Photo‐responsive/activable nanomedicine‐driven therapies have emerged as a transformative approach to effectively target and eliminate tumors across different types of solid cancers. When synergistically combined with immunomodulators, these therapies significantly enhance anti‐cancer efficacy. This comprehensive review examines the current advancements in photo‐responsive/activable immunomodulator‐loaded nanomedicines (PINs), providing a detailed analysis of their preclinical development, clinical translation, and associated research funding. The diverse PINs are systematically categorized, innovative design strategies are explored, and the underlying photo‐responsive/activable and immunomodulatory mechanisms are elucidated. By integrating clinical advancements with technical innovations and financial perspectives, this review bridges the translational gap, underscoring the immense potential of PINs to revolutionize cancer therapy. This comprehensive resource is indispensable for researchers striving to bring phototherapies to clinical fruition in the battle against cancer. |
| format | Article |
| id | doaj-art-eaa9a4ec87de4f918c1ad8d6551a6035 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-eaa9a4ec87de4f918c1ad8d6551a60352025-08-20T11:56:10ZengWileyAdvanced Science2198-38442025-08-011230n/an/a10.1002/advs.202417657Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for CancerDeepak S. Chauhan0Kun Shao1Roopa Hebbandi Nanjundappa2Daniel‐Jiajun Yu3Marianne Stanford4Huile Gao5Channakeshava Sokke Umeshappa6Department of Microbiology and Immunology Dalhousie University Halifax NS B3H 4R2 CanadaState Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116023 ChinaDepartment of Microbiology and Immunology Dalhousie University Halifax NS B3H 4R2 CanadaFaculty of Pharmacy Universite de Montreal Montreal QC H3T 1J4 CanadaDepartment of Microbiology and Immunology Dalhousie University Halifax NS B3H 4R2 CanadaKey Laboratory of Drug‐Targeting and Drug Delivery System West China School of Pharmacy Sichuan University Chengdu 610041 ChinaDepartment of Microbiology and Immunology Dalhousie University Halifax NS B3H 4R2 CanadaAbstract Photo‐responsive/activable nanomedicine‐driven therapies have emerged as a transformative approach to effectively target and eliminate tumors across different types of solid cancers. When synergistically combined with immunomodulators, these therapies significantly enhance anti‐cancer efficacy. This comprehensive review examines the current advancements in photo‐responsive/activable immunomodulator‐loaded nanomedicines (PINs), providing a detailed analysis of their preclinical development, clinical translation, and associated research funding. The diverse PINs are systematically categorized, innovative design strategies are explored, and the underlying photo‐responsive/activable and immunomodulatory mechanisms are elucidated. By integrating clinical advancements with technical innovations and financial perspectives, this review bridges the translational gap, underscoring the immense potential of PINs to revolutionize cancer therapy. This comprehensive resource is indispensable for researchers striving to bring phototherapies to clinical fruition in the battle against cancer.https://doi.org/10.1002/advs.202417657clinical trialsimmunotherapyphotodynamic therapyphotoimmunotherapyphotothermal therapy |
| spellingShingle | Deepak S. Chauhan Kun Shao Roopa Hebbandi Nanjundappa Daniel‐Jiajun Yu Marianne Stanford Huile Gao Channakeshava Sokke Umeshappa Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer Advanced Science clinical trials immunotherapy photodynamic therapy photoimmunotherapy photothermal therapy |
| title | Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer |
| title_full | Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer |
| title_fullStr | Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer |
| title_full_unstemmed | Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer |
| title_short | Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer |
| title_sort | comparative analysis of clinical outcomes and financial aspects of phototherapies and immunotherapy for cancer |
| topic | clinical trials immunotherapy photodynamic therapy photoimmunotherapy photothermal therapy |
| url | https://doi.org/10.1002/advs.202417657 |
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