Design and Rationale of the Phase 2 Baricitinib Study in Apolipoprotein L1–Mediated Kidney Disease (JUSTICE)

Design and Rationale of the Phase 2 Baricitinib Study in Apolipoprotein L1–Mediated Kidney Disease (JUSTICE)

Introduction: Individuals of recent West African ancestry develop focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (HTN-ESKD) at 4 times the rate of White Americans. Two protein-coding variants of the Apolipoprotein L1 (APOL1) gene, G1 and G2, explain 50...

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Bibliographic Details
Main Authors: Opeyemi A. Olabisi, Nadine J. Barrett, Anika Lucas, Maurice Smith, Kenisha Bethea, Karen Soldano, Stephanie Croall, Azita Sadeghpour, Hrishikesh Chakraborty, Myles Wolf
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Kidney International Reports
Subjects:
African American
APOL1
proteinuria
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024924018102
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