Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors
Tumors of the gastrointestinal system represent a significant share of solid tumors worldwide. Despite the advances in diagnosis and treatment, the prognosis of gastrointestinal tumors is still very poor and improved therapies are indispensable. Cytokine-induced killer (CIK) cells are feasible for a...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/897214 |
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| author | Clara E. Jäkel Annabelle Vogt Maria A. Gonzalez-Carmona Ingo G. H. Schmidt-Wolf |
| author_facet | Clara E. Jäkel Annabelle Vogt Maria A. Gonzalez-Carmona Ingo G. H. Schmidt-Wolf |
| author_sort | Clara E. Jäkel |
| collection | DOAJ |
| description | Tumors of the gastrointestinal system represent a significant share of solid tumors worldwide. Despite the advances in diagnosis and treatment, the prognosis of gastrointestinal tumors is still very poor and improved therapies are indispensable. Cytokine-induced killer (CIK) cells are feasible for an immunotherapeutic approach as they are easily available and have an advantageous biologic profile; they are rapidly proliferating and their high cytotoxicity is non-MHC-restricted. We summarize and discuss twenty recent clinical studies applying CIK cells for the treatment of gastric, pancreatic, hepatocellular, and colorectal cancer. Autologous CIK cells were transfused intravenously, intraperitoneally, or via the common hepatic artery. In all studies side effects and toxicity of CIK cell therapy were mild and easily controllable. The combination of CIK cell therapy with conventional adjuvant or palliative therapies was superior to the standard therapy alone, indicating the benefit of CIK cell therapy for cancer patients. Thus, CIK cells represent a promising immunotherapy for the treatment of gastrointestinal tumors. The optimal treatment schedule and ideal combination with conventional therapies should be evaluated in further clinical studies. |
| format | Article |
| id | doaj-art-eaa5aa0509724e568f871204322262b3 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-eaa5aa0509724e568f871204322262b32025-08-20T02:22:02ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/897214897214Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal TumorsClara E. Jäkel0Annabelle Vogt1Maria A. Gonzalez-Carmona2Ingo G. H. Schmidt-Wolf3Center for Integrated Oncology (CIO), University Medical Center Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, GermanyDepartment of Internal Medicine I, University Medical Center Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, GermanyDepartment of Internal Medicine I, University Medical Center Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, GermanyCenter for Integrated Oncology (CIO), University Medical Center Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, GermanyTumors of the gastrointestinal system represent a significant share of solid tumors worldwide. Despite the advances in diagnosis and treatment, the prognosis of gastrointestinal tumors is still very poor and improved therapies are indispensable. Cytokine-induced killer (CIK) cells are feasible for an immunotherapeutic approach as they are easily available and have an advantageous biologic profile; they are rapidly proliferating and their high cytotoxicity is non-MHC-restricted. We summarize and discuss twenty recent clinical studies applying CIK cells for the treatment of gastric, pancreatic, hepatocellular, and colorectal cancer. Autologous CIK cells were transfused intravenously, intraperitoneally, or via the common hepatic artery. In all studies side effects and toxicity of CIK cell therapy were mild and easily controllable. The combination of CIK cell therapy with conventional adjuvant or palliative therapies was superior to the standard therapy alone, indicating the benefit of CIK cell therapy for cancer patients. Thus, CIK cells represent a promising immunotherapy for the treatment of gastrointestinal tumors. The optimal treatment schedule and ideal combination with conventional therapies should be evaluated in further clinical studies.http://dx.doi.org/10.1155/2014/897214 |
| spellingShingle | Clara E. Jäkel Annabelle Vogt Maria A. Gonzalez-Carmona Ingo G. H. Schmidt-Wolf Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors Journal of Immunology Research |
| title | Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors |
| title_full | Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors |
| title_fullStr | Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors |
| title_full_unstemmed | Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors |
| title_short | Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Gastrointestinal Tumors |
| title_sort | clinical studies applying cytokine induced killer cells for the treatment of gastrointestinal tumors |
| url | http://dx.doi.org/10.1155/2014/897214 |
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