Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies

Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies

Abstract Nigrostriatal dopaminergic degeneration in alpha-synucleinopathies is indirectly reflected by low dopamine transporter (DaT) uptake through [123I]FP-CIT-SPECT. Bulk magnetic susceptibility ( $$\chi$$ ) in the substantia nigra, from MRI-based quantitative susceptibility mapping (QSM), is a p...

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Main Authors:	Oliver C. Kiersnowski, Pietro Mattioli, Lucia Argenti, Laura Avanzino, Francesco Calizzano, Andrea Diociasi, Laura Falcitano, Chunlei Liu, Mattia Losa, Federico Massa, Silvia Morbelli, Beatrice Orso, Elisa Pelosin, Stefano Raffa, Matteo Pardini, Dario Arnaldi, Luca Roccatagliata, Mauro Costagli
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Series:	Scientific Reports
Subjects:	Alpha-synucleinopathies Quantitative susceptibility mapping DECOMPOSE Susceptibility source separation Parkinson’s disease Prodromal alpha-synucleinopathies
Online Access:	https://doi.org/10.1038/s41598-024-83593-z
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